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I dose up on vitamin C, drink lots of water, and a larger quantity of warm drinks (hot cocoa, tea, tea especially if my throat is bothering me). And if it's so miserable I just can't stand being awake I double dose the NyQuil and knock myself out.
I have different results with antihistamenes and such so I generally only resort to those if I need to stay awake and make it through a day of working or school, but I try to avoid getting other people sick, and simply rest.
My mother would go all out, get wrapped in warm bedding, have a humidifier next to the bed, plenty of 7-up and chicken noodle soup, getting sick wasn't such a bad thing as a child. It just sucks now, miss out on way too much.
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