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saltfish · 05-10-2004, 08:18 PM

The hardness of a drug could be defined by the residual effects, both emotionally and physicially on the body and mind. It could also be said that the hardness of a drug is directly related to it's potential for abuse.

Many of the opiates, drugs that stimulate opiate receptors and subsequantly dopamine levels in the brain are regarded as 'high risk for abuse', one reason for their status on the DEA list. Other drugs like PCP, LSD and such, have a potential for abuse, though their effects on the mind are far more detremental.
I have seen many cases where friends/acquaintances have used LSD on only a few occasions, yet they have changed perminantly. LSD, in particular, work with certain parts of the brain's chemistry that cannot be undone; once LSD has been metabolized in the brain, perminant damage has been done.

---------

I would also like to add to the above discussion about Ecstacy. Ecstacy has many hidden dangers, especially when considering the effects on brain chemisty. Without going into great detail about 'reuptake' and neurotransmitters, let's just for times sake, say that, chemicals that are used to communicate between brain cells, that aren't used immedietly, are used again by said cells. This process of recapturing neurotransmitters is called re-uptake.
Now, with a brain that it under the influence of MDMA, or ectstacy, as there is a sudden and extreme release of 5-HT and other chemicals, there is an opportunity for dopamine and seritonin to 'uptake' into the incorrect areas. Studies have shown that reuptake of seritonin into a dopamine vessicle could lead to the oxidizing of said seritonin molecule and creating a PEROXIDE byproduct. Now, we all know what PEROXIDES do to organic matter; imaging duping hydrogen peroxide onto your brain, not a good thing to do. Of course this is on a far smaller scale, but when one thinks about neuron regeneration, they remember that it does NOT happen. You are born with a majority of the neurons that you will have your entire life. One must also consider that with frequancy of use comes the greatest deal of damage; using MDMA a few times puts you at a small risk, but taking the drug in multiple doses, frequantly for a long period of time puts you at a GREAT risk for physicial brain damage. This does not include the emotional damage from the psychological implications of MDMA.

/Wishes he hadn't done SO much.

-SF

noahfor · 05-11-2004, 05:09 AM

Quote:

once LSD has been metabolized in the brain, perminant damage has been done.

I know it wasn't your intention, but statements like that are easily misinterpreted and lead to less acceptance of drugs and people that use them. When people hear brain damage, they think dying neurons. LSD does not cause that kind of brain damage. It can sometimes "change the way the brain works" in a way that leaves the taker worse off emotionally and psychologically, but that certainly doesn't happen every time. It can leave the taker better off psychologically and emotionally as well. LSD is sometimes given to patients during therapy to increase the effectiveness of it. I think I have also read that they do this with mdma, and the doctor himself will take it.

I got these statements from an LSD faq at erowid.com, a very reputable drug reasource page.

"Zero physical addiction potential.

Essentially zero psychological addiction potential.

Purely psychological hazards, not harmful to body.

Lethal (toxic) doses of LSD are conservatively several tens of
thousands of times as much as a normal dose, making it (in the toxic sense) one of the safest drugs known.

Nevertheless, given all of the negative press and propaganda about LSD, it is quite an eye-opener to take it for the first time and to experience its (and one's own) Divine nature, not to mention how inaccurate and biased the media portrayal of it is.
"
Try ingesting 10, 000 beers and then get back to me.

Here is a summary of a study done of the neurological effects of chronic LSD users:

Quote:

We studied 21 subjects, each of whom had ingested LSD an average of 65 times. This group was found to be different from nondrug groups on several EEG measures. Using a computer analysis of their EEGs we found an increased abundance of delta, theta, alpha, and beta activity. Such findings could be related to the presence of the drug within their systems, to central nervous system dysfunction, personality factors, or to the subjects' attitudes during the EEG recording sessions. There was no increase in the expected number of clinically abnormal EEG records in these subjects. When the records were read using usual clinical criteria, several records were judged to be poorly organized and showed increased fast and slow activity of the type that may be related to the effects of drugs but is also frequently found in other individuals in this age group.

EEG evoked potential studies of electrical response to specific stimuli were also done. On a measure which has been found to be sensitive to intellectual disorganization in schizophrenia, the auditory two-tone evoked potential, this group showed no abnormality. They also appeared normal, although perhaps slow, on visual information processing tasks. However, on visual evoked potential procedures they gave evidence of being uniquely sensitive to low intensity stimulation and, in contrast to non-LSD- using groups, there was no relationship between their evoked responses to visual stimuli and their subjective response to the intensity of tactile stimuli. They seemed to modulate and organize sensory input in a different fashion.

Some of the people in the study had taken LSD 300 times.

The human brain is constanly changing, and rearranging itself. Every single stimulus and thought changes the brain. A substances changing the brain sounds alot worse than it really is. I'm not saying they can't change the brain in bad ways; I'm just saying that the fact that they change the brain doesn't really mean anything.

saltfish · 05-11-2004, 05:48 AM

Noahfor, I understand where you're comming from.

Though can't we assume that what is 'floating' around as LSD now adays may be a poorly synthesized version that is more apt to cause damage?

-SF

05-10-2004, 08:18 PM	#41 (permalink)
saltfish !?!No hay pantalones!?! Location: Indian-no-place	The hardness of a drug could be defined by the residual effects, both emotionally and physicially on the body and mind. It could also be said that the hardness of a drug is directly related to it's potential for abuse. Many of the opiates, drugs that stimulate opiate receptors and subsequantly dopamine levels in the brain are regarded as 'high risk for abuse', one reason for their status on the DEA list. Other drugs like PCP, LSD and such, have a potential for abuse, though their effects on the mind are far more detremental. I have seen many cases where friends/acquaintances have used LSD on only a few occasions, yet they have changed perminantly. LSD, in particular, work with certain parts of the brain's chemistry that cannot be undone; once LSD has been metabolized in the brain, perminant damage has been done. --------- I would also like to add to the above discussion about Ecstacy. Ecstacy has many hidden dangers, especially when considering the effects on brain chemisty. Without going into great detail about 'reuptake' and neurotransmitters, let's just for times sake, say that, chemicals that are used to communicate between brain cells, that aren't used immedietly, are used again by said cells. This process of recapturing neurotransmitters is called re-uptake. Now, with a brain that it under the influence of MDMA, or ectstacy, as there is a sudden and extreme release of 5-HT and other chemicals, there is an opportunity for dopamine and seritonin to 'uptake' into the incorrect areas. Studies have shown that reuptake of seritonin into a dopamine vessicle could lead to the oxidizing of said seritonin molecule and creating a PEROXIDE byproduct. Now, we all know what PEROXIDES do to organic matter; imaging duping hydrogen peroxide onto your brain, not a good thing to do. Of course this is on a far smaller scale, but when one thinks about neuron regeneration, they remember that it does NOT happen. You are born with a majority of the neurons that you will have your entire life. One must also consider that with frequancy of use comes the greatest deal of damage; using MDMA a few times puts you at a small risk, but taking the drug in multiple doses, frequantly for a long period of time puts you at a GREAT risk for physicial brain damage. This does not include the emotional damage from the psychological implications of MDMA. /Wishes he hadn't done SO much. -SF

05-11-2004, 05:48 AM	#43 (permalink)
saltfish !?!No hay pantalones!?! Location: Indian-no-place	Noahfor, I understand where you're comming from. Though can't we assume that what is 'floating' around as LSD now adays may be a poorly synthesized version that is more apt to cause damage? -SF