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Yakk 10-23-2006 07:18 AM

Stem Cell Research
 
I ran into this Micheal J Fox political ad:
http://www.youtube.com/watch?v=a9WB_PXjTBo&eurl=

Mr Fox was a well known actor. He has Parkinsons at an unusually young age. You can see what it does to his nervous system in the above ad.

On the issue of "Stem Cell Research", McCaskill is in favour, while Talent puts forward anti-stem cell/cloning arguments like "I don't want to be walking down the street and run into myself".

I suspect opposing "Stem Cell Research" was a short-term gain, and a medium and long-term mistake on the part of the Republicans in congress. People sick with fatal deseases can quite blatantly say "slowing stem cell research will kill me, and kill others like me". It is a pretty damn powerful message.

The short term gain the Republicans cashed in on was the support of Zealot Christian groups, who view any kind of scientific advancement (especially in the Biological sciences) with extreme fear and prejudice.

Finally, I salute Mike. Standing up in front of a State or a Nation and saying "I'm crippled, look at me" is not the easiest thing in the world.

Edit: moved
"Gah -- this was supposed to be in Politics, not Philosphy. It could be a decent Philosophical debate, but I was focused on the Politics of the issue...

Could a moderator move this to Politics please?"
from the start of the post. Moderator moved the post. Thanks!

filtherton 10-23-2006 07:26 AM

Yeah, i'm always amazed at how much "respect for life" the social conservatives have concerning anything reproductive compared to their almost complete disregard for life when it comes to many things political and economic.

If only there was some way that we could blame fetuses (feti?) for their predicament... Then this whole issue wouldn't exist. We could do to the fetuses what we do to all "parasitic classes" and let them twist in the wind, maybe grudgingly throw them a bone now and then.

Infinite_Loser 10-23-2006 09:38 AM

Embryonic stem cell research should be ditched and the focus turned solely to adult stem cell research, as the latter has produced more results (Someone correct me if I'm wrong). If that were to happen, most-- If not all-- Of the opposition to stem cell research would dissipate, as the moral obligation to the fetus would be gone (No fetus = No moral obligation).

NCB 10-23-2006 12:11 PM

The American people are ignorant about the facts of embryonic stem cell research. There are people in this country (and on this very board) that think research on ESC is banned and that is not the case at all. They dont even understand the issue is. The most successful stem cell research being done now is on adult stems cells and stem cells umbilical cord blood. I wonder if Michael Fox knows that, and if he does, has no problem pimping out his illness for a political candidate?

Willravel 10-23-2006 12:17 PM

I'm against abortion but pro stem cell research. Isn't that wierd?!

NCB 10-23-2006 12:23 PM

Quote:

Originally Posted by willravel
I'm against abortion but pro stem cell research. Isn't that wierd?!

Not really. I think most people, including myself, are on the same boat

Willravel 10-23-2006 12:25 PM

Quote:

Originally Posted by NCB
Not really. I think most people, including myself, are on the same boat

Yes, but you are a social conservative and I am a social liberal. I'm also anti-death penalty, and anti-war.

NCB 10-23-2006 12:34 PM

Quote:

Originally Posted by willravel
Yes, but you are a social conservative and I am a social liberal. I'm also anti-death penalty, and anti-war.

Well, regardless of labels, the fact remains that most people agree with the position on abortion and SC research

Ustwo 10-23-2006 01:59 PM

Quote:

Originally Posted by Yakk
I suspect opposing "Stem Cell Research" was a short-term gain, and a medium and long-term mistake on the part of the Republicans in congress. People sick with fatal deseases can quite blatantly say "slowing stem cell research will kill me, and kill others like me". It is a pretty damn powerful message.

And those people are wrong too. Maybe the cure can be found in those stem cells from dead babies, maybe not, but thats an invalid stance to take. Stem cell research is going on in other parts of the globe, guess what, those guys are still crippled. Now mind you the capitalistic medicine system in the US does make our research better than most socialist systems you see in the western world, but there is still nothing to say stemcell research will cure ANY disease. If my kid had a digenerative disease I'd be first in line pushing for stem cell research, but thats just pure selfish motivation. I'd beat you to death with your own arms if it meant saving my child, so we need to step back from the emotionalism.

My personal stance is that if people are flushing their babies we might as well use them as they have already been killed, and even if I were a fundamentalist Christian I would have that stance. Much like using the Nazi hypothermia research, it would be research gained from an evil source but the evil was already done, and I'm all for some good comming out of evil. Its even easier since I don't view the act as evil but simply a new form of genetic selection.

Paq 10-23-2006 03:58 PM

stranger things have happened, but not in a while..but

i agree wtih ustwo..again

I just don't see how using the remains for research could be negative. it's a tragedy that they occur, but something good could come from it. What is the problem with that?

btw, i did not know Michael J Fox's condition had deteriorated so much. Gotta agree with Yakk..the repubs screwed up royally for a short term gain. wasn't reagan's son at the DNC in 2004?

connyosis 10-23-2006 04:05 PM

Quote:

Originally Posted by Paq
...
btw, i did not know Michael J Fox's condition had deteriorated so much...

Well see, according to Rush Limbaugh it hasn't. Fox was simply off his meds to make his appearance more dramatic, the liberal bastard.

http://www.crooksandliars.com/2006/1...tor-after-all/

Honestly, Limbaugh has to be the scum of the earth...

Ustwo 10-23-2006 05:01 PM

Rush speaks on this.


Quote:


Democrats Exploit Michael J. Fox's Illness
October 23, 2006



BEGIN TRANSCRIPT
Now, people are telling me that they have seen Michael J. Fox in interviews and he does appear the same way in the interviews as he does in this commercial for Claire McCaskill. All right, then I stand corrected. I've seen him on Boston Legal. I've seen him on a number of stand-up appearances. I know he's got it; it's pitiable that he has the disease. It is a debilitating disease, and I understand that fully. Just stick with me on this.

All I'm saying is I've never seen him the way he appears in this commercial for Claire McCaskill. So I will bigly, hugely admit that I was wrong, and I will apologize to Michael J. Fox, if I am wrong in characterizing his behavior on this commercial as an act, especially since people are telling me they have seen him this way on other interviews and in other television appearances.

BREAK TRANSCRIPT
Let me just say this about it. The reason I went and grabbed the audio from John Edwards, where he said in 2004 on the campaign trail, "If we can do the work that we can do in this country, the work we will do when John Kerry is president, people like Christopher Reeve are going to walk, get up out of that wheelchair and walk again." That was about stem cells, and that was a misleading statement, and it didn't work for the Breck Girl, implying that if it weren't for George W. Bush and his stubbornness on stem cells that we've got a cure for spinal deterioration and injury, and we don't. We do not have anywhere near a cure. We can't we regenerate nerves yet, folks, and that's what has to happen to cure paralysis in the spine. Stem cells do not promise any such thing, nor do they for Parkinson's disease. So the reason that I went and got the Breck Girl to compare it to Michael J. Fox is because I think the intent here is the thing. I think, if I may be blatantly honest, brazenly so, I think this is much more offensive than Hillary's Senate opponent implying that she's ugly.

Michael J. Fox is allowing his illness to be exploited and in the process is shilling for a Democrat politician. In the process of doing that, creating an impression like John Edwards tried to do that is not reality. Michael J. Fox is using his illness as a way to mislead voters into thinking that their vote for a single United States Senator has a direct impact on stem cell research in Missouri. It doesn't, and it won't. So Mr. Fox is using his illness as another tactic to try to secure the election of a Democrat senator by implying that with her election, that we'll be on the road to stem cell research her opponent opposes and people who suffer from Parkinson's disease as he does will have a cure. It's a negative ad, and negative ads work, and people criticize them all the time as I am doing to this one, but when you see it, there's something wrong about it in the get-go. It's the exploitation of someone's illness. I wonder if this would become a trend and all kinds of illness were being exploited how people would end up reacting to it and feeling about it. So if this was not an act, then I apologize. I've not seen this type of appearance by Michael J. Fox before and that's why it struck me the way it did. But despite all that, I mean it's pitiable and it's very sad anybody has this disease, because it is debilitating in ways that people that don't have it don't even understand. But to exploit it like this in misrepresenting the political agenda of a particular candidate, there's nothing admirable about that.

BREAK TRANSCRIPT
I must share this. I have gotten a plethora of e-mails from people saying Michael J. Fox has admitted in interviews that he goes off his medication for Parkinson's disease when he appears before Congress or other groups as a means of illustrating the ravages of the disease. So lest there be any misunderstanding, we talked about a half hour ago of the commercial that's running for Claire McCaskill featuring Michael J. Fox on what appears to be when he's off his meds. I have never seen him this way and I stated when I was commenting to you about it that he was either off his medication or acting. He is an actor after all, and started hearing from people, "Oh, no, I've seen him on TV this way, this is how the disease has affected him when he's not on his medications." Then the e-mails started coming in saying he's admitted not to taking them in certain circumstances so as to illustrate how the disease affects people. All of which I understand, and I'm not even critical of that. Parkinson's disease is hideous.

Let me just stress once again in what I said in closing this out, that I think this is exploitative in a way that's unbecoming either Claire McCaskill or Michael J. Fox, because in this commercial for Claire McCaskill he's using his illness in a way to mislead voters that there's a cure for Parkinson's disease if only Claire McCaskill gets elected, if only Jim Talent is defeated. And of course it's all about stem cell research, which is a huge ballot initiative in Missouri anyway. I'm sorry, Missoura. He pronounced it Missoura. There are two ways to pronounce my home state, Missouri and Missoura. And Missoura, in certain sectors is the preferred pronunciation. It is a way to relate to certain Missourans. We never say Missourans, we say Missourians. But it's a way to reach out, "I understand you, I know your state" and so forth. There's a lot of politics in the commercial. But Mr. Fox was allowing his illness to be used as a tactic to trying to secure the election of a Democrat senator who is going to somehow, her election is going to lead to the cure for Parkinson disease via stem cell research because her opponent, Jim Talent, opposes it, which is not true. He may oppose embryonic stem cell research, does not oppose adult stem cell research or even cord blood, I don't believe, research, umbilical cord research.

The comparison is obvious, and that is to the Breck Girl, John Edwards, who did the same thing by saying Christopher Reeve will walk again if only John Kerry is elected because we will do the work that needs to be done. And that kind of thing, when you start making false promises to people who suffer from diseases like this that are horrible and debilitating, when you start telling them that there's a cure right around the corner if only somebody gets elected, you are misleading them, you are creating a creating a false-hope scenario, and that is cruel, if you ask me, that is cruel and it is mean to lead people to believe that we are much further along in research than we are. There's nobody involved in the research who is saying we're anywhere near any kind of a cure for spinal disease, paralysis, Parkinson's, Alzheimer's. In fact, the closest we are to Alzheimer's is nicotine. I mean supposedly nicotine will limit or lessen the impact of Alzheimer's down the road. And now they're also saying it about pot, the evil weed.

So let there be no misunderstanding about this. I stand corrected, did not know and had never seen Michael J. Fox in the way I saw him in this commercial for Claire McCaskill. But people have and have seen him say in interviews that he doesn't take his medications when he wants to make an impression to show people just how horrible the disease is. And it's true of all Parkinson's patients. At some point the medication will not work, and the condition will become permanent, and there's nothing pleasant about it. It's one of the most frustrating diseases one can have. Pope had it. It's not pleasant in any way, shape, manner, or form, nor did I mean to implicate that one could easily act it out for the purposes of a commercial.

Paq 10-23-2006 05:26 PM

i think rush needs more vicodin

Infinite_Loser 10-23-2006 05:32 PM

As I stated earlier, just do away with embryonic stem cell research and only focus on adult stem cell research, as not only is it more productive but the moral implications which are involved in embryonic stem cell research don't exist with adult stem cell research (As you're mainly using skin and spinal cord cells).

jorgelito 10-23-2006 05:37 PM

Quote:

Originally Posted by Infinite_Loser
As I stated earlier, just do away with embryonic stem cell research and only focus on adult stem cell research, as not only is it more productive but the moral implications which are involved in embryonic stem cell research don't exist with adult stem cell research (As you're mainly using skin and spinal cord cells).

I don't know very much on this topic, but this sounds reasonable to me.

dc_dux 10-23-2006 05:40 PM

We wont know the value of embryonic stem cell research until more research is conducted on embryonic stem cells to determine for a fact that adult stem cells are equally productive. There is no conclusive evidence that I have seen to support this conclusion.

And I have a hard time seeing the moral implications. It is not like embryos are being created for the purpose of stem cell research, which should never be allowed. The idea is to utlize the thousands of existing embryos created "in vitro" and that will otherwise be disposed. The potential life saving possibilities, as slim as they may be until we know more, is a reasonable alternative to disposal.

Just as an aside, would we even have millions of couples that have benefited from in vitro fertilization if we had been prevented from exploring the boundaries of medical science as a result of the moral concerns expressed by a less than majority segment of society?

jorgelito 10-23-2006 07:03 PM

DC, you make some interesting points but I would like to know more. How do you know it is less than a majority of the population that has a moral concern with this issue? Also, even if it is less than a majority, would that matter? After all, there have been case in the past where the majority was not in the right.

It's a complex issue butI think there can be a compromise there. More discussion and civil debate is definitely a good thing.

hiredgun 10-23-2006 08:00 PM

I genuinely, honestly don't understand what the problem is with stem cell research. Being that it is a science with great potential like any other, I am for supporting it fully and wholeheartedly; to the extent that scientists are willing and able to pursue this research, I can think of no reason to limit them and plenty of reasons to positively support them, without reservation.

So can someone who thinks otherwise (whether you're against it, or simply have reservations or qualifications) please explain their position to me?

This isn't meant as a rhetorical challenge; I'm actually curious and just would like to hear frank responses. I'm not asking you to prove anything to me.

dc_dux 10-23-2006 08:18 PM

Quote:

Originally Posted by jorgelito
DC, you make some interesting points but I would like to know more. How do you know it is less than a majority of the population that has a moral concern with this issue? Also, even if it is less than a majority, would that matter? After all, there have been case in the past where the majority was not in the right.

It's a complex issue butI think there can be a compromise there. More discussion and civil debate is definitely a good thing.

I was looking at the variety of polls on stem cell research. Most show a majority supporting embryonic stem cell research.

http://pollingreport.com/science.htm#Stem

I believe that if it was explained that it doesnt mean creating new embryos for the research but using existing embryos that would otherwise be destroyed, the numbers would be even higher...but that is conjecture.

Cutting edge science always has to deal with the moral implications regardless of the level of public support. But in this case, there are potential medical benefits that cant be fully determined without research and public support.

Ustwo 10-23-2006 08:27 PM

Actually I did think of a problem with stem cell research that I had forgotten about.

I will NEVER EVER support discarded human fetuses as a commodity. If anyone is making money off them, I do view that as wrong, and I can just imagine if it became a market where breeder women sell the right to their abortion.

That is one horror I would not abide by.

dc_dux 10-23-2006 08:37 PM

The bill that Bush vetoed with the statement "these boys and girls are not spare parts" restricts the research:

Quote:

This legislation does NOT allow funding for the creation or destruction of embryos. This is already outlawed in the annual Dickey-Wicker Amendment that is attached as a rider to the Labor HHS Education Appropriations Bill. Rather it allows federally funded research on stem cell lines derived ethically according to the following principles:

* The stem cells were derived from human embryos that have been donated from in vitro fertilization clinics, were created for the purposes of fertility treatment, and were in excess of the clinical need of the individuals seeking such treatment. Prior to the consideration of embryo donation and through consultation with the individuals seeking fertility treatment, it was determined that the embryos would never be implanted in a woman and would otherwise be discarded.

* The individuals seeking fertility treatment donated the embryos with written informed consent and without receiving any financial or other inducements to make the donation.

As you can see this legislation for the first time aims to end the "Wild West" of stem cell research by establishing an ethical construct. It also does not expand funding for embryonic stem cell research. I think the most critical aspect of this policy is that the embryos we are discussing are blastocysts, created for the purposes of in vitro fertilization, developed into a few hundred cells, no bigger than the tip of a pencil, and which are spare or in excess of clinical need and in every single case are slated for medical waste. In keeping with your principles, the "life and death" decision has been made - the donors have decided to discard these embryos and they will be discarded. Why not use the stem cells we can derive from these embryos, which will never become life, to help the millions of people suffering across the United States?

http://www.house.gov/castle/pr_06_SC...entletter.html
So I am not accused of taking the Bush statement out of context:
PRESIDENT BUSH: Yet we must also remember that embryonic stem cells come from human embryos that are destroyed themselves. Each of these human embryos is a unique human life, with inherent dignity and matchless value. We see that value in the children who are with us today. Each of these children began his or her life as a frozen embryo that was created for in vitro fertilization, but remained unused after fertility treatments were complete. Each of these children was adopted while still an embryo, and has been blessed with the chance to grow up in a loving family. These boys and girls are not spare parts.
According to the background from the Castle bill, only 10 percent of the "in vitro" embryos not used by the primary parents are "adopted" and the rest destroyed.

jorgelito 10-23-2006 09:41 PM

Quote:

Originally Posted by hiredgun
I genuinely, honestly don't understand what the problem is with stem cell research. Being that it is a science with great potential like any other, I am for supporting it fully and wholeheartedly; to the extent that scientists are willing and able to pursue this research, I can think of no reason to limit them and plenty of reasons to positively support them, without reservation.

So can someone who thinks otherwise (whether you're against it, or simply have reservations or qualifications) please explain their position to me?

This isn't meant as a rhetorical challenge; I'm actually curious and just would like to hear frank responses. I'm not asking you to prove anything to me.

Well I suppose I am against it by default. But I am not blindly opposed to it. It's just that I am unsure because I simply do not understand it. I get so many different takes on the issue.

My starting point would be abortion. I am against abortion through and through. No compromise there. My reason is that for me, I need science or a consensus by clergy determine when life actually began (i.e. - at conception or at birth or somewhere in between). But until then, I believe life to begin at conception. SO abortion to me would be murder plain and simple.

Stem cell research as I understand it thus far, requires the stem cells from an embryo or fetus. That's where things get murky for me. I hesitate because while I understand that those embryos or fetuses are to be discarded regardless, I share the same concern as UsTwo with the potential for trade or commerce in fetuses and embryos. This I cannot abide. Especially if there were to be a trade in aborted fetuses etc....

Now this new info you guys are talking about, the adult stem cell research stuff, is definitely intriguing to me. I don't know anything about it really but I am open-minded enough to listen.

That's it for now, I need to take a break, but I hope that helps you understand one opposing opinion, HiredGun.

FoolThemAll 10-24-2006 04:29 AM

Quote:

Originally Posted by hiredgun
I genuinely, honestly don't understand what the problem is with stem cell research.

To put it simply: Embryos are human life and scientific research requiring the destruction of human life is wrong.

I agree with Ustwo's point, too, but that isn't the main thing for me.

And yes, I also have a problem with in vitro fertilization.

edit: seems that jorgelito put together a much more thorough explanation, feel free to address his post instead... I'll only add that I don't see any good reason for opposing adult stem cell research and don't personally know anyone who opposes it. It's the embryonic stuff that gets a minority of religious folk and secular oddities like me upset.

Yakk 10-24-2006 10:56 AM

There is a ban against using federal funds to do embriotic stem cell research.

Now, on the face of this, it doesn't seem to be that huge of a ban.

But you have to remember something. Not one penny.

Not one penny of federal funds, from the past or the present, could have been used in any equipment, buildings, administration, or salaries. If the building was made 20 years ago, paid for from a fund that got 1% of it's input from Federal funding -- you can't do any stem cell research in that building.

Even if it is just one penny of Federal funding that went into the building, using it for stem cell research is illegal.

So, either you have to do a huge accounting backtracking check to find and guarantee a research building is federal-funding free, from now and back to the beginning of time, and then sequester it off from the main revenue of the research institution (to prevent it from being contaminated with Federal funds), or you have to build a completely seperate and sequestered research institution and avoid contaminating it with Federal funds.

Don't get me wrong -- this is being done. There are US universities that refuse Federal funding, and I believe there has been some attempts in California to build stem cell research buildings.

But the Federal ban on stem cell research isn't just "the Fed's won't earmark any funds for Stem Cell research" -- it means that anyone who ever accepted Federal money is retroactively constrained (to a greater or lesser extent) in what they can do.

...

I was actually under the impression, after doing some research, that M.J.F.'s rocking behaviour during that add was a side effect of a drug that helps him speak more clearly. (the claim is that without his meds, at the current time, MJF cannot effectively speak)

The drug kills the small-scale tremours, and allows speech -- but it causes a significant low-frequency rocking motion.

Ustwo 10-24-2006 11:42 AM

Quote:

But the Federal ban on stem cell research isn't just "the Fed's won't earmark any funds for Stem Cell research" -- it means that anyone who ever accepted Federal money is retroactively constrained (to a greater or lesser extent) in what they can do.
So you need a new building and some research eq? Few million, its covered, paying the lab people would be more in the long run of course. Having worked in such labs there is not much too them really.

Perhaps rather than spending ones effort to elect people to publicly fund, the best course of action would be to privately fund it, if there is such a public desire to see it happen.

Maybe a stem-cell telethon ;)

magictoy 10-24-2006 08:02 PM

Quote:

Originally Posted by connyosis
Well see, according to Rush Limbaugh it hasn't. Fox was simply off his meds to make his appearance more dramatic, the liberal bastard.

http://www.crooksandliars.com/2006/1...tor-after-all/

Honestly, Limbaugh has to be the scum of the earth...

A quote from your link:

Quote:

These emails claim Fox has admitted in interviews that he goes off his medication." A tireless search of the Internet produces no such record of any interview, or any statement in which Fox has ever admitted or even suggested that he ever goes off his Parkinson's treatment at all, let alone for the purposes of shaking it up for the television audience.
But FROM HIS OWN WEBSITE:

http://www.michaeljfox.org/news/arti...p?id=153&sec=2

Quote:

When he testified before Congress back in 1998 seeking more funds for the disease, he made a point of not taking any Parkinson's drugs so his tremors and other symptoms would be in full bloom. "I needed to show there was an urgency to this," Mr. Fox says, noting that at the time he was still a regular -- and healthy-appearing -- presence on television. With his story and condition now better known, he no longer needs to forgo his medicines to make a dramatic point.
I'm not against stem cell research, and I don't mind that he went off his meds. Once again, though, Rush is called "the scum of the earth" for thinking that Michael might have done something he admitted to in the past.

They're not "tireless," but it seems obvious who the "crooks and liars" are, and the lies they're willing to tell to influence the next election.

Willravel 10-24-2006 08:23 PM

How dare people try to cure Parkinson's! Damn crooks. :rolleyes:

How about what we do is give Limbaugh Parkinson's, then we can let him see what it's like when you are dying slowly from a crippling disease. He'd be rallying for stem cell research in a split second, and then O'Reilly would be all over his ass. Then we give O'Reilly Parkinson's, and someone else is on his ass. The whole thing is dispicable. How about instead of shooting down a possible cure, these idiot pundits get off their fat asses and try to fucking help?

Ustwo 10-24-2006 09:22 PM

Quote:

Originally Posted by willravel
How dare people try to cure Parkinson's! Damn crooks. :rolleyes:

How about what we do is give Limbaugh Parkinson's, then we can let him see what it's like when you are dying slowly from a crippling disease. He'd be rallying for stem cell research in a split second, and then O'Reilly would be all over his ass. Then we give O'Reilly Parkinson's, and someone else is on his ass. The whole thing is dispicable. How about instead of shooting down a possible cure, these idiot pundits get off their fat asses and try to fucking help?

Using a disease for your political purposes while dangling the possibility of a cure that no one is even sure will come of the research at all isn't exactly nobel. Its exploitative. Vote for me and you will walk again! No not really but thanks for the vote.

This might be hard for you to gasp but SOME people view abortion as murder, I'm not going to fault them for this, I'm not so sure myself. I'm just evil and think that if people want to murder their children more power too them as those people won't be teaching their children their own fucked up values in the next generation.

Seaver 10-25-2006 05:41 AM

Sorry, but look up the bill that he is trying to get passed.

It's not to legalize stem-cell research, that research is legal and Talent has stated he has NO plan to criminalize it.

It's a constitutional bill which is labeled the Stem-Cell Research and Protection (or something similar), look it up and you'll realize that this mis-label is actually to constitutionally protect cloning.

Michael J. Fox thinks he is helping stem-cell research when in reality he's helping cloning research. While I support stem-cell, I am completely against cloning.

dc_dux 10-25-2006 05:58 AM

Perhaps you can explain how the bill that both the House and Senate passed and Bush vetoed contitutionally protects cloning.

Quote:

SECTION 1. SHORT TITLE.

This Act may be cited as the `Stem Cell Research Enhancement Act of 2005'.

SEC. 2. HUMAN EMBRYONIC STEM CELL RESEARCH.

Part H of title IV of the Public Health Service Act (42 U.S.C. 289 et seq.) is amended by inserting after section 498C the following:

`SEC. 498D. HUMAN EMBRYONIC STEM CELL RESEARCH.

`(a) In General- Notwithstanding any other provision of law (including any regulation or guidance), the Secretary shall conduct and support research that utilizes human embryonic stem cells in accordance with this section (regardless of the date on which the stem cells were derived from a human embryo).

`(b) Ethical Requirements- Human embryonic stem cells shall be eligible for use in any research conducted or supported by the Secretary if the cells meet each of the following:

`(1) The stem cells were derived from human embryos that have been donated from in vitro fertilization clinics, were created for the purposes of fertility treatment, and were in excess of the clinical need of the individuals seeking such treatment.

`(2) Prior to the consideration of embryo donation and through consultation with the individuals seeking fertility treatment, it was determined that the embryos would never be implanted in a woman and would otherwise be discarded.

`(3) The individuals seeking fertility treatment donated the embryos with written informed consent and without receiving any financial or other inducements to make the donation.

`(c) Guidelines- Not later than 60 days after the date of the enactment of this section, the Secretary, in consultation with the Director of NIH, shall issue final guidelines to carry out this section.

`(d) Reporting Requirements- The Secretary shall annually prepare and submit to the appropriate committees of the Congress a report describing the activities carried out under this section during the preceding fiscal year, and including a description of whether and to what extent research under subsection (a) has been conducted in accordance with this section.'.

hiredgun 10-25-2006 06:04 AM

Thanks to those who clarified their stance for me.

Seaver, do you have a link on that info?

UsTwo: Of course a cure isn't a sure thing, but no research ever is. The point is that there's a possibility, and that possibility is too valuable not to be pursued. If the lives of our adult, fully human soldiers are worth the possibility of whatever we think we're achieving in Iraq, is the use of a few dead fetuses not an acceptable price for the possibility to preserve life by fighting disease?

FoolThemAll 10-25-2006 06:17 AM

Quote:

Originally Posted by hiredgun
If the lives of our adult, fully human soldiers are worth the possibility of whatever we think we're achieving in Iraq, is the use of a few dead fetuses not an acceptable price for the possibility to preserve life by fighting disease?

I'd say that there's one big difference between those two situations: consent.

The people in the armed forces - as it's currently all-volunteer - all consented to be enforcers of United States foreign policy. You could say that they didn't consent to this particular war - and perhaps there's a good argument there - but there is basic, general consent. An embryo cannot consent. I don't see the donor's consent as being sufficient for life-discarding medical research, just as I wouldn't consider consent from the parent of an infant sufficient (which is not to say that there aren't differences between the two situations, just not any relevant differences in my view).

dc_dux 10-25-2006 06:24 AM

We're not talking about "dead fetuses".....the issue is embryos from in vitro that would otherwise be discarded.

FoolThemAll 10-25-2006 06:46 AM

Quote:

Originally Posted by dc_dux
We're not talking about "dead fetuses".....the issue is embryos from in vitro that would otherwise be discarded.

Which is why I also have a problem with in vitro fertilization in its current form (and possibly all other feasible forms).

I'd agree that use for research is better than destruction for extra space or destruction according to the donor's wishes, but I don't believe that any of these should be legally permitted. Let alone taxpayer-funded.

Willravel 10-25-2006 07:31 AM

Quote:

Originally Posted by Ustwo
Using a disease for your political purposes while dangling the possibility of a cure that no one is even sure will come of the research at all isn't exactly nobel. Its exploitative. Vote for me and you will walk again! No not really but thanks for the vote.

Stem cell research looks, to experts, like the most promising route to go for a cure to Parkinson's. Experts. Not politicans or actors or pundits or even message board posters. While the rest may bicker, the opinion that matters belongs to the experts, scientists that understand Parkinson's and stem cells better than you or I or Rush. When I say that stem cells can cure something, it's meaningless. When Rush states that Michael J. Fox is this and that, it's meaninless and cruel. At the end of the day, people should learn to listen to doctors and scientists, not assholes on the radio, or people on a forum.
Quote:

Originally Posted by Ustwo
This might be hard for you to gasp but SOME people view abortion as murder, I'm not going to fault them for this, I'm not so sure myself. I'm just evil and think that if people want to murder their children more power too them as those people won't be teaching their children their own fucked up values in the next generation.

Actually it's not hard for me to grasp at all. From the fifth post in this thread:
Quote:

Originally Posted by Willravel, the brave
I'm against abortion but pro stem cell research. Isn't that wierd?!

I'm against abortion except in the cases of incest, there being no chance that the baby will be born alive, or maybe, MAYBE rape - but the victim better have taken that morning after pill, and if a hospital refused to give her the pill, that hospital should be promptly closed. I belive in sexual accountability, even though most other liberals disagree with me on this issue. There are other sources of stem cells, too. Did you know that the umbilical cord blood is a great source of stem cells? We've know about this for years. And babies are born almost every minute of every day. If we were able to immediatally collect all the umbilical cords (after the infant is done with it), I doubt we'd need another source for stem cells. I even just came up with a motto: Save a life, donate an umbilical cord. Or maybe: Save an embryo, donate an umbilical cord. Whatever. The point is: stem cells isn't really a devisive topic, or at least it shouldn't be. The only reason it's a deviceive issue, of course, is to distract people. It's like gay marriage or "Merry Christmas" versus "Happy Holidays". It's stupid, and I don't know why people walk right into the trap. It's another device to spread the partisan epidemic, and the longer this kinda stuff is allowed to fly, the longer it will take under democrat leadership to get back to normal.

hiredgun 10-25-2006 07:52 AM

Quote:

Originally Posted by FoolThemAll
I'd say that there's one big difference between those two situations: consent.

The people in the armed forces - as it's currently all-volunteer - all consented to be enforcers of United States foreign policy. You could say that they didn't consent to this particular war - and perhaps there's a good argument there - but there is basic, general consent. An embryo cannot consent. I don't see the donor's consent as being sufficient for life-discarding medical research, just as I wouldn't consider consent from the parent of an infant sufficient (which is not to say that there aren't differences between the two situations, just not any relevant differences in my view).

Fine. What about the lives of Iraqis?

Ustwo 10-25-2006 07:56 AM

Quote:

Originally Posted by dc_dux
Perhaps you can explain how the bill that both the House and Senate passed and Bush vetoed contitutionally protects cloning.


(1) The stem cells were derived from human embryos that have been donated from in vitro fertilization clinics, were created for the purposes of fertility treatment, and were in excess of the clinical need of the individuals seeking such treatment.


These stem cells are pretty much worthless for any disease research, its basically nothing beyond an egg. They are totally non-differentiated, and there isn't much we can do with them except let them differentiate, aka develop. This is very useful for the study of cloning (an identical twin is a natural clone) but won't make M.J. Fox stop shaking.

Quote:

Originally Posted by hiredgun
UsTwo: Of course a cure isn't a sure thing, but no research ever is. The point is that there's a possibility, and that possibility is too valuable not to be pursued. If the lives of our adult, fully human soldiers are worth the possibility of whatever we think we're achieving in Iraq, is the use of a few dead fetuses not an acceptable price for the possibility to preserve life by fighting disease?

:hmm:

That comparison is a weee bit of a stretch. The obvious counter argument is that the fetuses didn't volunteer to be killed.

The_Jazz 10-25-2006 07:58 AM

Quote:

Originally Posted by willravel
Experts. Not politicans or actors or pundits or even message board posters.

...

Did you know that the umbilical cord blood is a great source of stem cells? We've know about this for years. And babies are born almost every minute of every day. If we were able to immediatally collect all the umbilical cords (after the infant is done with it), I doubt we'd need another source for stem cells. I even just came up with a motto: Save a life, donate an umbilical cord. Or maybe: Save an embryo, donate an umbilical cord. Whatever.

Don't you think that this has occurred to the experts as well? My understanding is that these stem cells aren't suitable for the needs of the scientists. Granted, I'm just a message board poster too, but if you came up with this idea, don't you think that the people paid to think about this topic all day every day have already come up with it?

/threadjack and rational thought

hiredgun 10-25-2006 07:59 AM

Ustwo: I refer you to the post right above yours. If we're willing to sacrifice the lives of Iraqis, I don't understand the unwillingness to use these embryos.

The comparison is a huge stretch, imo; on the one hand you have discarded embryos that have never been born or lived, and on the other you have adult humans who have lives, memories, and families.

Willravel 10-25-2006 08:01 AM

Quote:

Originally Posted by The_Jazz
Don't you think that this has occurred to the experts as well? My understanding is that these stem cells aren't suitable for the needs of the scientists. Granted, I'm just a message board poster too, but if you came up with this idea, don't you think that the people paid to think about this topic all day every day have already come up with it?

/threadjack and rational thought

Well here's a bit more rational thought for you: who funds most scientists? Is it more scientists?

dc_dux 10-25-2006 08:03 AM

Quote:

These stem cells are pretty much worthless for any disease research, its basically nothing beyond an egg. They are totally non-differentiated, and there isn't much we can do with them except let them differentiate, aka develop.
Ustwo....can you source that please....wtih a credible medical source?

Ustwo 10-25-2006 08:28 AM

Quote:

Originally Posted by dc_dux
Ustwo....can you source that please....wtih a credible medical source?

Sure hes my source:

Ustwo, B.S. D.D.S. M.S., worked in a genetics lab for two years as well. Now taking out the pure dentistry stuff, that’s 11 years of biology study after high school. Its also something anyone who was a basic biology major should be able to figure out on their own without any advanced work. What they are talking about is a fertilized egg, or at most a blastocyst. There isn't much we are going to learn from a human fertilized egg beyond what we know in other mammals because the initial stages of development are all almost identical. The only real use I can see of it is to perfect human cloning.

Quote:

Originally Posted by hiredgun
Ustwo: I refer you to the post right above yours. If we're willing to sacrifice the lives of Iraqis, I don't understand the unwillingness to use these embryos.

The comparison is a huge stretch, imo; on the one hand you have discarded embryos that have never been born or lived, and on the other you have adult humans who have lives, memories, and families.

:lol:

Ok this is quite funny really. Instead of Iraqi's you could use someone who died in a police hostage standoff, or maybe the 40k a year who die in car crashes in the US every year.

Lets try it on for size....

If you are willing to sacrifice 40,000 people a year in traffic accidents I don't understand the unwillingness to use those embryos.

Or maybe this one.....

If you are willing to eat apples I don't understand your unwillingness to eat oranges.

Ok now that I got that silliness aside, I am IN favor of using those dead babies but I can respect those who view it as murder. The difference is I don't play philosophical games to sooth my conscious over it. I think abortion is murder, I just don't care that much since I view it as genetic selection removing undesirable traits from humanity. If people want to step out of the gene pool in such a selfish and brutal manner I don't want those genes in the next generation, and we might as well get some good from their irresponsibility.

hiredgun 10-25-2006 09:00 AM

Quote:

Originally Posted by Ustwo
Ok this is quite funny really. Instead of Iraqi's you could use someone who died in a police hostage standoff, or maybe the 40k a year who die in car crashes in the US every year.

Lets try it on for size....

If you are willing to sacrifice 40,000 people a year in traffic accidents I don't understand the unwillingness to use those embryos.

Or maybe this one.....

If you are willing to eat apples I don't understand your unwillingness to eat oranges.

That doesn't make any sense.

The Iraqi deaths I'm talking about were preventable and are a direct result of a political decision to go to war, one that you support. In this case, the loss of life is, to you, worth what we might potentially achieve (but so far have not done).

But when it comes to stem cell research, it appears that the possible or potential benefits to medicine are not worth the loss of mere embryos.

You don't see a contradiction there when it comes to the value placed on life? What's 'silly' about this?

Willravel 10-25-2006 09:09 AM

Quote:

Originally Posted by Ustwo
Sure hes my source:

Ustwo, B.S. D.D.S. M.S., worked in a genetics lab for two years as well. Now taking out the pure dentistry stuff, that’s 11 years of biology study after high school.

Now I'm really confused. You have experience in the field that pertains to this discussion, so you get to call upon and cite your training and experience in order to make you an expert, but meinwhile:
Quote:

Originally Posted by Ustwo
Yea well thats your opinion, I have mine, though mine doesn't have cool red letters. You can also find people who think you shouldn't spank your child, and I don't agree with them either, just like you can find psychologists who think violent behavior is due to low self esteem. I'm willing to go with the opinion of all of human history over some psychobabble.

Personally I'd hope they use a case by case basis. Some people will crack easily under torture, others will respond better to kindness, I would hope we have our own interrogation experts deciding whats the best method with each individual.

http://www.tfproject.org/tfp/showpos...5&postcount=70

...you ignore other prople's expertise, training and experience. A BA, and well on my way to getting a Masters in psych puts what I say above "psychobabble", doesn't it? Just like your 11+ years of bio training after high school means that you are qualified to give an (basically) expert opinion on stem cells?

So either you have to start listening to other experts, or you yourself will cease to be an expert. You can't have it both ways.

The_Jazz 10-25-2006 09:33 AM

Quote:

Originally Posted by willravel
Well here's a bit more rational thought for you: who funds most scientists? Is it more scientists?

:lol: The funding fairy? Alan Greenspan? Ustwo? :p

Just kidding about that last one. We all know he wouldn't fund anything that wasn't already pure evil. :D

Seriously, I don't see the point of your question to my response. Mine was more of "the good ideas have already been thought of already" variety. If scientists figured out how to do their research with more readily available materials, they're going to do it, especially if the results are going to yield easy cures for fatal diseases. If you're implying that scientists are ignoring easily available material in pursuit of more funding, let's see your proof. I assume that's not what you're trying to tell me, though.

/interruption of the dick-measuring contest

Willravel 10-25-2006 09:45 AM

Quote:

Originally Posted by The_Jazz
:lol: The funding fairy? Alan Greenspan? Ustwo? :p

Just kidding about that last one. We all know he wouldn't fund anything that wasn't already pure evil. :D

Seriously, I don't see the point of your question to my response. Mine was more of "the good ideas have already been thought of already" variety. If scientists figured out how to do their research with more readily available materials, they're going to do it, especially if the results are going to yield easy cures for fatal diseases. If you're implying that scientists are ignoring easily available material in pursuit of more funding, let's see your proof. I assume that's not what you're trying to tell me, though.

/interruption of the dick-measuring contest

Hey, he called mine small....


The idea is that scientists and researchers might be hindered in their abilities and exploration by those that fund them is nothing new. I know that scientists and researchers are out there to cure this and that, but they have to pander to their benificiaries or lose their funding. We all know that. It would be niave to say that science isn't effeced by politics. Did we already forget about the Dickey Amendment? Clinton signed federal legislation that prohibited the HHS from using appriopriated funds for any stem cell research in which the embryo is destroyed. I'm sure Ustwo can tell you that does cut a lot of funding for stem cell research, and it's a decision made on (religous?) morality, not science. They aren't ignoring anything, they simply aren't funded so they CAN'T do their research.

Yakk 10-25-2006 10:03 AM

Yes, you'd have to build up a completely different instuition in order to do research unretricted by the Federal ban provisions on fetal stem-cell research.

This is basic research. The kind that helps everyone in the USA -- a damn good use of Federal money. Instead, Federal money is making it harder to do the research.

The fetal stem cells are the least differentiated human cells out there. Learning how to convince them to differentiate and turn into arbitrary tissue is ridiculously interesting research.

Do you object to having the Federal government fund fundamental scientific research? Do you understand the economic basis for why funding fundamental scientific research is a damn good idea?

The_Jazz 10-25-2006 10:25 AM

Will, are you seriously telling me that there's a vast conspiracy amongst the research institutions of the world to use embryonic stem cells solely? Or that umbilical stem cells and embryonic stem cells are even the same thing (I honestly don't know).

dc_dux 10-25-2006 10:34 AM

Quote:

Originally Posted by Ustwo
Sure hes my source:

Ustwo, B.S. D.D.S. M.S., worked in a genetics lab for two years as well. Now taking out the pure dentistry stuff, that’s 11 years of biology study after high school. Its also something anyone who was a basic biology major should be able to figure out on their own without any advanced work. What they are talking about is a fertilized egg, or at most a blastocyst. There isn't much we are going to learn from a human fertilized egg beyond what we know in other mammals because the initial stages of development are all almost identical. The only real use I can see of it is to perfect human cloning.

Then should no trouble citing a collaborating source.

Ustwo 10-25-2006 10:51 AM

Quote:

Originally Posted by dc_dux
Then should no trouble citing a collaborating source.

*Sigh* I'm not here to do your homework, look it up yourself. You posted the bill, I showed you why it has nothing to do with 'stemcell research' as a cure for a disease, and you want me to prove to you basic developmental biology?

If I'm wrong show me, otherwise accept it from someone who has forgotten more biology than you will learn in your lifetime.

dc_dux 10-25-2006 11:13 AM

Perhaps this letter of support for the bill in question from the American Association of Medical Colleges:

Quote:

"The therapeutic potential of pluripotent stem cells is remarkable and could well prove to be one of the important paradign-shifting advances in the history of medical science. These cells have the unique potential to differentiate into any human cell type and offer real hope of life-affirming treatments for diabetes, damaged heart tissue, arthritis, Parkinsons, ALS, and spinal cord injuries, to name but a few examples. There is also the possibility that these cells could be used to create more complex organ structures that could replace vital damaged organs..."

http://www.aamc.org/advocacy/library...005/030205.pdf
And since I didnt know what pluripotent stem cells are:
Quote:

Pluripotent stem cells are descendants of the totipotent stem cells of the embryo. These cells, which develop about four days after fertilization, can differentiate into any cell type, except for totipotent stem cells and the cells of the placenta.

http://www.stemcellresearchfoundatio...bout/FAQ.htm#1
hmmmm....weighing the credibility....Dr two v AAMC

Willravel 10-25-2006 11:36 AM

Quote:

Originally Posted by The_Jazz
Will, are you seriously telling me that there's a vast conspiracy amongst the research institutions of the world to use embryonic stem cells solely? Or that umbilical stem cells and embryonic stem cells are even the same thing (I honestly don't know).

Worst strawman ever. So I say that some researchers are and could be losing funding because of legislation, then I cite prescedent, then you claim that I am suggesting that there is a massive conspiracy? Are you and Ustwo doing a tag team thing now? It's like I can't say anything without people trying to valiently stop me from making another far-fetched conspiracy claim. I'm not a conspiracy theorist, people.

Yakk 10-25-2006 12:13 PM

What is more important, in the short term, than the ethics of stem cell research is the political impact.

The banning of any institution accepting federal funding from doing embryonic stem cell research -- what have been, and will be, the political effects of it?

It did enhearten the anti-abortion troops -- it was a concrete step in vaguely that direction. In the short term, it couldn't help but bring volunteers to the Republicans, and motivate the anti-abortion voters to come out to the polls.

The other hand is the emotional impact of ads like Fox's. Getting in the way of extremely promising medical research that could cure thousands if not millions of people -- one can make political hay against the Republicans using that arguement.

The worst possible case would be if one of the non-Federal funded Embryonic Stem Cell research institutions where to pull off a breakthrough. This isn't likely in the short term -- we are talking about basic research -- but it would probably make a heck of alot of political ammunition.

...

As for the ethics of it... There are 4 kinds of stem cells:
Quote:

Originally Posted by wiki
* Totipotent stem cells are produced from the fusion of an egg and sperm cell. Cells produced by the first few divisions of the fertilized egg cell are also totipotent. These cells can differentiate into embryonic and extraembryonic cell types.

* Pluripotent stem cells are the descendants of totipotent cells and can differentiate into cells derived from the three germ layers.

* Multipotent stem cells can produce only cells of a closely related family of cells (e.g. hematopoietic stem cells differentiate into red blood cells, white blood cells, platelets, etc.).

* Unipotent cells can produce only one cell type, but have the property of self-renewal which distinguishes them from non-stem cells.

Adult stem cells are only 2 of the above 4 types. I am not aware of that any Pluripotent or Totipotent stem cells exist in adults. Maybe one can transform existing Puripotent stem cells backwards and to other kinds?

Possibly cutting open human brains and scraping out brain stem cells could be used for research. Personally, I'm against cutting peoples brains open and using an ice cream scoop. Somehow, I think that using fertilized eggs that are going to be discarded anyhow seems like a cleaner way to get nerve-cell precurors...

I suppose they could just scoop the brains of brain-dead people to harvest neuron stem cells?

That still doesn't get us access to nerve-cell (as opposed to brain-cell) precursors, as far as I know there aren't any in an adult body...

The_Jazz 10-25-2006 12:59 PM

Quote:

Originally Posted by willravel
Worst strawman ever.

Thank you, thank you all. I'm so excited to have even been nominated! There are so many people to thank that I hope that the orchestra doesn't play me off. Top of the world, ma! :love:

Quote:

So I say that some researchers are and could be losing funding because of legislation, then I cite prescedent, then you claim that I am suggesting that there is a massive conspiracy? Are you and Ustwo doing a tag team thing now? It's like I can't say anything without people trying to valiently stop me from making another far-fetched conspiracy claim. I'm not a conspiracy theorist, people.
No, what you suggested was that all scientists working on a problem were deliberately ignoring a potential source of material and that in their hellbent scheme to secure funding for embryonic stem cell research they buried the concept of using umbilical stem cells. Now I was a history major and I'm an insurance guy so I have no idea if that's even viable. Maybe it is, maybe it isn't. I'm, as you already put it, just a poster on a message board not a scientist. Maybe Ustwo can tell you, but I'm sure that he's off drinking more water to keep his urine production up to keep pissing in everyone's Cheerios. Again, if you've got evidence that umbilical stem cells can fit the purpose of embryonic ones, I'd love to here it.

Speaking of Ustwo, I'm sure he's as offended as I am at the thought of being tag team partners. Don't make me go all Randy Macho Man Savage on you.

Willravel 10-25-2006 01:53 PM

So I said all? Show me, or end the theadjack.

The_Jazz 10-25-2006 03:17 PM

Quote:

Originally Posted by willravel
So I said all? Show me, or end the theadjack.

See your posts #35 and #46. Relevant quotes:

Quote:

There are other sources of stem cells, too. Did you know that the umbilical cord blood is a great source of stem cells? We've know about this for years. And babies are born almost every minute of every day. If we were able to immediatally collect all the umbilical cords (after the infant is done with it), I doubt we'd need another source for stem cells. I even just came up with a motto: Save a life, donate an umbilical cord. Or maybe: Save an embryo, donate an umbilical cord.
Quote:

The idea is that scientists and researchers might be hindered in their abilities and exploration by those that fund them is nothing new. I know that scientists and researchers are out there to cure this and that, but they have to pander to their benificiaries or lose their funding. We all know that. It would be niave to say that science isn't effeced by politics. Did we already forget about the Dickey Amendment? Clinton signed federal legislation that prohibited the HHS from using appriopriated funds for any stem cell research in which the embryo is destroyed. I'm sure Ustwo can tell you that does cut a lot of funding for stem cell research, and it's a decision made on (religous?) morality, not science. They aren't ignoring anything, they simply aren't funded so they CAN'T do their research.
Maybe I read to much into it, but given our exchanges, these are the starting points of your arguements. See my post #45 for earlier confusion in your point and trying to clarify.

FoolThemAll 10-25-2006 08:11 PM

Quote:

Originally Posted by hiredgun
Fine. What about the lives of Iraqis?

Well, it depends.

The Iraqis who attempt violence against U.S. troops and/or other Iraqis? Self-defense. Whatever their reasons, no matter how noble, a response to lethal force can still fall into the realm of self-defense.

The Iraqis who didn't attempt violence, yet were killed? It's that unfortunate, not-yet-eliminated cost of war known as collateral damage.

I'm suddenly a little confused as to what you consider the great big inconsistency here, and moreover I'm wondering why it's relevant to this thread if there's an inconsistency. It's possible to be wrong about one issue and right about another. Would you prefer a foolish consistency?

lewk 10-27-2006 04:36 AM

Who's dime is it all on?

I'm all for making it legal so Michael J. Fox can invest his money in discarded fetuses to try to cure a disease he didn't care about until he realized he had it, but, please, keep my tax dollars out of this.

hiredgun 10-27-2006 07:03 AM

Quote:

Originally Posted by FoolThemAll
Would you prefer a foolish consistency?

Would I prefer a shred of internal consistency over seeming hypocrisy? Yes, actually.

And the reason I introduced the idea into this thread is because it's a relevant criticism of people's objections to this research. What's stopping you from considering embryos to be the collateral damage of curing disease and advancing human knowledge? It is, by any measure, a smaller toll than the lives of full grown humans.

dc_dux 10-27-2006 07:17 AM

Quote:

Originally Posted by lewk
Who's dime is it all on?

I'm all for making it legal so Michael J. Fox can invest his money in discarded fetuses to try to cure a disease he didn't care about until he realized he had it, but, please, keep my tax dollars out of this.

Despite Ustwo's unsupported claim that embryonic stem cells are pretty much worthless for any disease research, the greatest benefit of public funding is to ensure that the intellectual property rights gained from such research is accessible for both further public and private research to build on.

Ustwo 10-27-2006 07:48 AM

Quote:

Originally Posted by dc_dux
Despite Ustwo's unsupported claim that embryonic stem cells are pretty much worthless for any disease research, the greatest benefit of public funding is to ensure that the intellectual property rights gained from such research is accessible for both further public and private research to build on.

When did I say that?

You don't understand the biology at all, yet have strong opinion on it, and thats just wonderful.

If you don't know the difference between a fetus, a embryo, a blastocyst or a fertilized egg, and what is going on at that point you have absolutely no business trying to discuss it beyond the most vague terms. If you have such a strong opinion that you feel the need to voice it here do some reading first and then come back.

I'll even do the first google for ya...
http://users.rcn.com/jkimball.ma.ult...velopment.html

Now when you have a grasp of cell differentiation, and development and what that bill you posted entails, come back.

FoolThemAll 10-27-2006 07:54 AM

Quote:

Originally Posted by hiredgun
Would I prefer a shred of internal consistency over seeming hypocrisy? Yes, actually.

I don't see the value of consistency when it's a consistency composed of bad ideas. Hypocrisy strikes me as preferable.

Quote:

And the reason I introduced the idea into this thread is because it's a relevant criticism of people's objections to this research.
Or, instead, a relevant criticism of people's acceptance of collateral damage. The problem: you don't really have any control over which it is.

I could say: "Okay, you're right, both collateral damage and embryonic stem cell research should be legal."

Or I could say: "Okay, you're right, both collateral damage and embryonic stem cell research should be illegal."

Or - and this'll be my final answer, Regis - I could respond in this way:

Quote:

What's stopping you from considering embryos to be the collateral damage of curing disease and advancing human knowledge?
War, in its entirety, should be an act of self-defense and/or defense of others. If it's neither, it is an unjust war. Collateral damage is a cost of such defense. If the war is properly justified, then the collateral damage is justified. Or rather, less worse than the alternative of no military response ever.

Embryonic stem cell research, on the other hand, cannot be properly considered self-defense or defense of others. The aggressor is nature, not man, and to respond to the injuries of nature by attacking man is wrong. Think of it this way: you wouldn't approve of harvesting organs from healthy infants in order to sustain the life of a sick adult, would you? Obviously this isn't a comparison of identical situations, experimenting with a clump of cells is a hell of a lot easier to rationalize for one, but I see a valid comparison there with no relevant difference. Beating nature isn't worth nonconsensual sacrifices of human life.

And that, I believe, is where our truly relevant disagreement lies. We may disagree on the whether collateral damage is acceptable in war, but I'm betting that we actually agree that collateral damage isn't acceptable in medical research. If not, well, then we have two relevant disagreements...but collateral damage in war remains irrelevant. Even if there is inconsistency remaining, it says nothing about whether I'm right on this issue.

The big question reverts back to this: does the lethal use of embryos for medical purposes differ in a morally significant way from doing the same with infants?

Quote:

It is, by any measure, a smaller toll than the lives of full grown humans.
Perhaps from the perspective of the victims' friends (embryos aren't very social), but not for the victims.

dc_dux 10-27-2006 08:48 AM

Quote:

Originally Posted by Ustwo
When did I say that?

You don't understand the biology at all, yet have strong opinion on it, and thats just wonderful.

If you don't know the difference between a fetus, a embryo, a blastocyst or a fertilized egg, and what is going on at that point you have absolutely no business trying to discuss it beyond the most vague terms. If you have such a strong opinion that you feel the need to voice it here do some reading first and then come back.

I'll even do the first google for ya...
http://users.rcn.com/jkimball.ma.ult...velopment.html

Now when you have a grasp of cell differentiation, and development and what that bill you posted entails, come back.

I was simply referring to your analysis of the section of the bill I posted:

Quote:

The bill: (1) The stem cells were derived from human embryos that have been donated from in vitro fertilization clinics, were created for the purposes of fertility treatment, and were in excess of the clinical need of the individuals seeking such treatment.

Your analysis: These stem cells are pretty much worthless for any disease research, its basically nothing beyond an egg. They are totally non-differentiated, and there isn't much we can do with them except let them differentiate, aka develop. This is very useful for the study of cloning (an identical twin is a natural clone) but won't make M.J. Fox stop shaking.
You are absolutely correct that I have no expertise in cell biology.

I do understand the public policy process fairly well, which requires interested observers, including members of Congress who ultimately make the decisions, to objectively evaluate the testimony and analysis of the experts on this or any subject up for public debate. I choose to give more credence to experts other than you.

Yakk 10-29-2006 07:28 AM

Where, exactly, is the "collateral damage" in taking discarded human cells, and using it?

The cells are going to be killed. You may object to the process that led to cells going to be killed, but once you have some being who has no ability to think, is doomed to die, and has useful organs or cells -- where is the ethical problem with harvesting it?

You do know that what I described is the source of almost all human organ transplants.

xxSquirtxx 10-29-2006 06:35 PM

Sadly, it appears that MJF was not as informed as he thought he was.

http://www.floppingaces.net/2006/10/...ng-initiative/

dc_dux 10-29-2006 07:15 PM

I dont particularly care if Fox read the details of the MO initiative or not. He was aware that it allows only stem cell research that complies with federal laws and regulations and that it prohibits human cloning.

That said, the position of Senate candidates on federal stem cell legislation should be more important to the rest of the country (whether you are for or against a federal bill) and the current Senator in MO voted against the bill that passed in both the House and Senate.

magictoy 10-29-2006 07:21 PM

Quote:

Originally Posted by Ustwo
When did I say that?

You don't understand the biology at all, yet have strong opinion on it, and thats just wonderful.

If you don't know the difference between a fetus, a embryo, a blastocyst or a fertilized egg, and what is going on at that point you have absolutely no business trying to discuss it beyond the most vague terms. If you have such a strong opinion that you feel the need to voice it here do some reading first and then come back.

I'll even do the first google for ya...
http://users.rcn.com/jkimball.ma.ult...velopment.html

Now when you have a grasp of cell differentiation, and development and what that bill you posted entails, come back.

You certainly nailed that down. Today more news came out along these lines, but squirt posted it first. Here is a different link than his, plus a quote:

http://hotair.com/archives/2006/10/2...ell-amendment/

Quote:

Stephanopoulos: In the ad now running in Missouri, Jim Caviezel speaks in Aramaic. It means, “You betray me with a kiss.” And his position, his point, is that actually even though down in Missouri they say the initiative is against cloning, it’s actually going to allow human cloning.

Fox: Well, I don’t think that’s true. You know, I campaigned for Claire McCaskill. And so I have to qualify it by saying I’m not qualified to speak on the page-to-page content of the initiative. Although, I am quite sure that I’ll agree with it in spirit, I don’t know, I— On full disclosure, I haven’t read it, and that’s why I didn’t put myself up for it distinctly

filtherton 10-29-2006 07:25 PM

Yeah, but i would wager most politicians don't know the page-to-page content of most bills.

magictoy 10-29-2006 07:25 PM

Quote:

Originally Posted by dc_dux
I dont particularly care if Fox read the details of the MO initiative or not. He was aware that it allows only stem cell research that complies with federal laws and regulations and that it prohibits human cloning.

Not according to George Stephanopoulos and Jim Caviezel.

Quote:

Originally Posted by dc_dux
That said, the position of Senate candidates on federal stem cell legislation should be more important to the rest of the country (whether you are for or against a federal bill) and the current Senator in MO voted against the bill that passed in both the House and Senate.

Yes, you would be well advised to attempt a subject change.

Quote:

Originally Posted by filtherton
Yeah, but i would wager most politicians don't know the page-to-page content of most bills.

Then if George Bush misspeaks on an issue, or doesn't choose the best course of action, he's doing nothing worse than the rest of Congress.

Nice to know you'll be cutting him slack for the rest of his term.

dc_dux 10-29-2006 07:29 PM

Quote:

Originally Posted by magictoy
Not according to George Stephanopoulos and Jim Caviezel.

Yes, you would be well advised to attempt a subject change.

Magic. I wonder if you or Squirt have you read the MO initiative?

Quote:

2. To ensure that Missouri patients have access to stem cell therapies and cures, that Missouri researchers can conduct stem cell research in the state, and that all such research is conducted safely and ethically, any stem cell research permitted under federal law may be conducted in Missouri, and any stem cell therapies and cures permitted under federal law may be provided to patients in Missouri, subject to the requirements of federal law and only the following additional limitations and requirements:

(1) No person may clone or attempt to clone a human being.

(2) No human blastocyst may be produced by fertilization solely for the purpose of stem cell research.

(3) No stem cells may be taken from a human blastocyst more than fourteen days after cell division begins; provided, however, that time during which a blastocyst is frozen does not count against the fourteen-day limit.

(4) No person may, for valuable consideration, purchase or sell human blastocysts or eggs for stem cell research or stem cell therapies and cures....

full text: http://www.sos.mo.gov/elections/2006...ppStemCell.asp
I am sure we can find competing analyses of the MO initiative, but the fact is that Fox said in a later interview that he knew it was limited only to stem cell research that complies with federal laws and that is why it is important for MO to have a senator that supported the bill that the majority of Congress (and the American people) wanted.

magictoy 10-29-2006 07:53 PM

Quote:

Originally Posted by dc_dux
Magic. I wonder if you or Squirt have you read the MO initiative?

Yes. In much the same way that you seem to have been too busy to click on Squirt's link, you were also too busy to read the entire initiative.

I won't post the link to the initiative again. You didn't read it when you posted it yourself.

Quote:

(2) “Clone or attempt to clone a human being” means to implant in a uterus or attempt to implant in a uterus anything other than the product of fertilization of an egg of a human female by a sperm of a human male for the purpose of initiating a pregnancy that could result in the creation of a human fetus, or the birth of a human being.
And, the following from Squirt's link:

Quote:

The act of implanting an embryo in a woman’s womb, performed with IVF embryos many times every day, is not what makes human cloning different. What is different is the act of cloning — somatic-cell nuclear transfer — by which the embryo is originally created. Cloning to produce an embryo to be developed to birth and cloning to produce an embryo to be destroyed for research are both human cloning, carried out identically. As James Battey, chair of the NIH Stem Cell Task Force, told a congressional committee in March, “The first step, the cloning step, is the same, but the intended result is different” (emphasis added). But the initiative, by redefining cloning, protects the practice while pretending to prohibit it.

Moreover, the combination of the first and second sections of the initiative would mean that the Missouri constitution would first privilege and protect the creation of cloned human embryos for research (as long as federal law did not prohibit it) and then would mandate the destruction of these embryos.
I'm sure Filtherton would be willing to give the framers of the initiative a break. They were probably too busy to read what they were writing.

host 10-29-2006 07:53 PM

Quote:

Originally Posted by xxSquirtxx
Sadly, it appears that MJF was not as informed as he thought he was.

http://www.floppingaces.net/2006/10/...ng-initiative/

Some of the state legislators in Missouri are batshit crazy religious fundamentalists. IMO, the purpose of the Missouri initiative 2 on the Nov.7 ballot is to prevent the legislature from narrowing whatever stem cell research federal law allows, and to prevent the state government from using funding restrictions to further narrow federal law:
Quote:

http://patriotboy.blogspot.com/2006_...54131821528523
Missouri: Where mules and Jesus are king

Rep. David Sater
Missouri House of Representatives

Dear Rep. Sater,

I want to thank you personally for sponsoring the resolution making Jesus Christ <a href="http://www.radicalruss.net/blog/2006/03/missouri_proposes_making_christianity_the_official.html">the Official God of the State of Missouri</a>. It's about time the state recognized that Jesus deserves the same exalted status as mules and paddlefish. I can't wait to see the poster.

I hope your bill is only the first step toward remaking Missouri into the new Zion. I long for the day when I see blasphemers, Buddhists, and sabbath violators locked up in stocks on the courthouse lawn. That'll set society right in a hurry, won't it.

But there are a couple of other tasks that need to be completed before the pillorying begins. First, you'll need to cleans the legislature of Satan's minions. You might consider starting with Rep. Susan Phillips. Sure, she seems like a god-fearing woman--her bill defending the parental rights of fathers who impregnate their daughters is proof of that--but her strange mutterings and the fact that her eyebrows don't move have convinced me that she might be a witch. If you're unsure, you might consider sitting next to her at a hearing and sticking her repeatedly with a pin to see of you can locate her devil's mark.

Next, you'll need to destroy Branson. If Las Vegas is the new Sodom, then Branson is definitely the new Gomorrah. Think about it. Aren't you ashamed that a town in your state markets itself as the home of acts like the Baldknobber's Jamboree and the Tall Timber Lumberjack Show. I bet the place is crawling with homosexuals.

Some might defend the Baldknobber's Jamboree for perpetuating positive stereotypes about the state and, thereby, counterbalancing the negative stereotypes the coastal elites promote about us, but dammit, the show is called the Baldknobber's Jamboree--I think that tells us all we need to know about their true agenda.

Others might argue Branson isn't all bad, citing shows like Act for God and the Lowe Family as examples of traditional family entertainment. But in Act for God's case, the title may be misleading. A picture on their website shows a skit featuring body parts. If you look closely, you'll notice a not-man standing between the head and the left hand. She's holding a ball. Case closed.

The Lowe Family is the exception that proves the rule. The part of their show where they re-enact raising the flag at Iwo Jima, albeit while wearing Liberace wear, is proof that they are not a part of Branson's hedonistic culture. Like Lott and his family, the Lowes should be spirited out of this New Gomorrah before it is leveled.

Well, that should be enough to give you a good start.

Heterosexually yours,

Gen. JC Christian, patriot

Update: I was going to call this update, David Sater is a better Christian than you. After all, he's not only a Baptist, he's a Methodist too. Then, I noticed that he's the music minister at the Methodist church in Shell Knob and that sounds just a little too dirty to me.

From his official House bio:

Rep. Sater is both a member of the First Baptist Church of Cassville and the United Methodist Church of Shell Knob, where he is with the music ministry of the church.

posted by Gen. JC Christian, Patriot | 3:06 AM
Quote:

http://www.stltoday.com/stltoday/new...D?OpenDocument
News > St. Louis City / County > Story
Stem cell debate heats up over wording
By Matt Franck
POST-DISPATCH JEFFERSON CITY BUREAU
10/29/2006

The political battle over a constitutional amendment to protect embryonic stem cell research has increasingly placed the ballot measure itself under the microscope, fueling bitter disagreement over its legal meaning.

At issue is how the 2,000-word amendment, which would protect all forms of federally legal stem cell research, would relate to the Missouri constitution and existing laws.

With a Nov. 7 vote approaching, television and radio ads by opponents have attempted to portray the measure as deceptive on issues such as human cloning, state funding and egg donation.

<b>But some arguments against the amendment are based on shaky legal footing, such as a claim that the measure would allow fetuses to be aborted to harvest human tissue. In fact, that practice is federally banned.

Other arguments have more to do with semantics than substance, particularly over dueling definitions of the term "human cloning."</b>

But those on both sides of the debate agree the ballot affects fundamental constitutional matters, such as the authority of the Legislature to pass laws and appropriate state funds.

And some legal experts say judges may have the final say on how some details of the amendment would play out.

An indirect approach

Disagreement on the issue roots largely from legal structure of the amendment, which some regard as unusual.

"It's peculiar in a lot of ways," said Carl Esbeck, a law professor at the University of Missouri at Columbia.

Esbeck is referring to the indirect way in which the amendment would protect certain forms of stem cell research.

In essence, the amendment does three things at once:

First, it states that all research legal under federal law shall be legal in Missouri. Second, it limits the authority of state and local governments in regulating the research. Finally, the amendment seeks to ban forms of research that are widely rejected by ethicists. Those include a ban on using cloning technology for reproductive purposes, as well as restrictions on the sale of human eggs.

The restrictions were include because there's currently virtually no regulation of the research at the federal level.

But much of the uproar over the amendment focuses on whether it truly bans what it claims to ban, particularly as it concerns human cloning and the sale of eggs.

The rest of the fight largely deals with the limits the amendment would place on state and local governments.

Legislators would retain the right to regulate health and safety issues, but not if doing so is designed to hamper research. Similar language limits legislators' ability to withhold state funds from institutions conducting research.

But exactly how those limits would play out in unclear.

"It does get tricky," Esbeck said.

"No" is called easier

Donn Rubin, of the Coalition for Lifesaving Cures, which supports the measure, said opponents have purposefully exaggerated claim about the measure, finding loopholes where there are none.

He describes the campaign as one of desperation, born from a realization that most voters have no moral objections to embryonic stem cell research.

"The strategy of defeating an amendment is to create doubts," he said. "It's easier to vote 'no' than to vote 'yes.'"

Opponents, meanwhile, aren't letting up with their strategy to portray the measure as deceptive, even if it means downplaying larger moral questions.

That was true in a recent statewide radio debate, in which a lead opponent of the measure twice refused to answer the question of whether the research destroys human life.

"No, that's really not the issue here," said Jaci Winship, of Missourians Against Human Cloning. "The issue here is a bold attempt to deceive the Missouri voter."
The argument that the amendment proposition "allows adult human cloning" is a key provision of the disinformation campaign of those who oppose the amendment's passage. IMO, if there were not "fringe" legislators who have already introduced state legislation proposals to officially designate Missouri as "Jesus Land", there would be no need for this amendment.....

Here's the relevant portion of Michael J. Fox's ABC interview transcript:
Quote:

http://abclocal.go.com/kgo/story?sec...ics&id=4707455
Oct. 29 - The actor tells ABC News' "This Week" about his disease, those controversial ads, and answers Rush Limbaugh's suggestion that he may have played up his illness for political effect. Read the full interview.......

.......Stephanopoulos: You mentioned the Steele campaign. Both the Steele campaign and the Talent campaign have said you're not being fair to them, because they want to expand stem cell research, too, they say, but it's adult stem cell research.

Fox: Right, and I agree with them on adult stem cell research. I mean, let's talk about what we agree on. I agree that stem cell research is fantastic; we should pursue it. I agree that we should have no human cloning. We're against that. We're against egg farming, that notion. We agree on all of that.

The only thing is, we would like to include embryonic stem cell research, which our scientists say has the best hope for cures and breakthroughs.

See, we're in agreement. I think that when they say talk about not being fair, there has been, again, not as much focus on the content of the ad. It's really the appearance of the ad. But really, because all the statements are verifiable and to direct comparison, it is, in effect, an ad for their position. If you see the ad and you agree with their position, and there are people that do, then it should incentive you to vote for them.

Stephanopoulos: In the ad now running in Missouri, Jim Caviezel speaks in Aramaic. It means, "You betray me with a kiss." And his position, his point, is that actually even though down in Missouri <b>they say the initiative is against cloning, it's actually going to allow human cloning.

Fox: Well, I don't think that's true. You know, I campaigned for Claire McCaskill. And so I have to qualify it by saying I'm not qualified to speak on the page-to-page content of the initiative. Although, I am quite sure that I'll agree with it in spirit, I don't know, I-- On full disclosure, I haven't read it, and that's why I didn't put myself up for it distinctly.</b>

But I've made this point before, and I really am sincere in it, that anybody who's prayed on this, and thought about it, and really considered it and can't get their mind around or their heart around the idea of embryonic stem cell research, I'd go to war for your right to believe that. And you're right to feel that. I respect it. I truly do.

My point is, and our point as a community, is we have a very good and supportable conclusion that a vast majority of people in this country are in favor of science playing a leading role in making changes in the future and believe in embryonic stem cell research.

So we're just saying, know that we have prayed on it, too, and we have thought about it, and we are good people, and we are family people, and we are people that take this very seriously, and we're as concerned as you are.

And we've decided that we would like to take this step and to do it with caution and to do it with oversight and to do it with the strictest adherence to ethics and all of the principles this country stands for.

But, allow us to do that without infusing the conversation with inflammatory rhetoric and name-calling and fear-mongering. It doesn't help.

Stephanopoulos: Do you think there's any way to finally find common ground with people who do believe in the end that this is tampering with tiny lives?

Fox: Well, again, the point has been made that these lives are going to be thrown away, anyway. They are marked for destruction -- thousands of frozen embryos that are a byproduct of in vitro fertilization. We have routinely, before this conversation started on stem-cell research, we have for years thrown them away.

And that's the other thing, you know, this idea of snowflake babies: We're in favor of that. The truth of the matter is that it is only going to account for a tiny fraction--

Stephanopoulos: Those are the embryos that are adopted and then brought

Fox: Absolutely. Who would have a problem with that? That's fantastic.

But it will, in the end, account for only a tiny fraction of those eggs. And so our point is that the pro-life position is to use that -- what up to this point is waste, of literal waste that is going to be thrown away -- use it to save lives and to ensure lives for the future. I mean, they talk about unborn. Unborn kids are going to be born with diabetes. People are going to be dealing with a genetic predisposition to Alzheimer's or to Parkinson's or kids that are going to be injured, have spinal cord injury.

That those kids may be born into a world that has the answers for that. That's our position.

dc_dux 10-29-2006 08:05 PM

Quote:

. In much the same way that you seem to have been too busy to click on Squirt's link, you were also too busy to read the entire initiative.
Magic.....You and I can read Squirts link, Host's link or any number of differing analysis, and its not likely to change either of our opinions.

I will continue to support candidates who would vote for the stem cell bill that Bush vetoed, against the majority support of Congress and the people, and I appreciate Michael J Fox's active involvement in the issue, particularly in light of the ridicule and criticism he has encountered.

filtherton 10-29-2006 10:45 PM

Quote:

Originally Posted by magictoy
Then if George Bush misspeaks on an issue, or doesn't choose the best course of action, he's doing nothing worse than the rest of Congress.

Nice to know you'll be cutting him slack for the rest of his term.

Are you trying to bust me out because you think i have more deference to congress than the president? Oooh, burn. They're all full of shit.

Anyways, i hope that you revile the president with as much vitriol as you have for mr. fox the next time he does something stupid, which, you know, should be any fucking minute now.

host 10-30-2006 01:54 AM

The religious right and elected republican officials in Missouri have a track record of interfering with women's access to reproductive information, treatment, and contraceptives...to a much more radical extent than at the federal level:

<b>At the following link, Missouri Gov. Matt Blunt allows the display of a deliberate, inciting falsehood:
RU-486 is never dispensed by pharmacists to prescription holders....</b>
Quote:

http://www.oa.mo.gov/bp/bib2007/Pro-Life.pdf
2006 Legislative Priority
Conscience Protection for Pharmacists
2006 Legislative Priority
Tax Credits to Support Alternatives to Abortion
25
2006 Legislative Priority
Prohibiting Abortion Providers from Teaching in Schools
2006 / Fiscal Year 2007 Priorities
Representing Missourians’ Values Currently, some school districts around the state allow Planned Parenthood and other abortion
providers to offer sex education in their schools. Governor Blunt believes that these providers
should not be providing information to Missouri school children. The Governor proposes
legislation:
• That will prohibit any public elementary or secondary institution from allowing abortion
providers to present sex education programs to students.
Currently, Missouri law provides conscience protection for certain medical professionals with
respect to abortions. <b>Recently, pharmacies have taken action against pharmacists who refuse to
fill prescriptions for RU-486 or the so-called morning after pill.</b> The Governor proposes
legislation that:
• Protects the conscience rights of pharmaceutical professionals.
Quote:

http://en.wikipedia.org/wiki/Mifepristone#_note-26

.....In the United States it is sold by Danco Laboratories under the tradename Mifeprex. (In some countries including the United States and Australia, the drug is still commonly referred to as "RU-486".).....

.....Mifepristone was approved under the second part of sub-section H. <b>The result is that women cannot pick the drug up at a pharmacy but must now receive it directly from a doctor.</b> Due to the possibility of adverse reactions such as excessive bleeding which may require a blood transfusion and incomplete abortion which may require surgical intervention, the drug is only considered safe if a physician who is capable of administering a blood transfusion or a surgical abortion is available to the patient in the event of such emergencies.[30] The approval of mifepristone under Subsection H included a black box warning.
http://www.fda.gov/ola/2006/mifepristone0517.html

<a href="http://www.commongroundcommonsense.org/forums/lofiversion/index.php/t51505.html">"If you hand out contraception to single women, we're saying promiscuity is OK as a state, and I am not in support of that," Phillips, R-Kansas City, said in an interview.</a>

The deliberation in the Missouri state senate in 2005 over this bill was the motivation for the vote on a constitutional amendment. Republicans who are not batshit crazy from religious influences, including gov. Matt Blunt, are presumably in favor of keeping the state on an equal footing with the rest of the countryas far as in the development of this science:

Quote:

http://www.missouricures.com/news_040605SLPD.php
NEWS ARTICLE
April 6, 2005
St. Louis Post-Dispatch
Missouri Senate shelves proposal for ban

By Matthew Franck
Post-Dispatch Jefferson City Bureau

JEFFERSON CITY, MO - After five hours of debate that pitted Republicans against Republicans on the most fundamental questions of human life, the Missouri Senate shelved a bill Wednesday that seeks to ban stem cell research involving cloning.

Now even the bill's sponsor, Sen. Matt Bartle, questions whether he has the political support to bring the matter back to the Senate floor later this session. "It's become pretty obvious to me a long time ago that there is more than enough political will to kill the bill," said Bartle, R-Lee's Summit.

Bartle's remarks came at the end of what some senators described as an agonizing debate over a research procedure that's viewed alternately as a salvation for the sick or the destruction of the earliest forms of life.

The debate saw senators sparring over genetic science in arcane detail. They spoke passionately of the ravages of disease and paralysis, including that of one of their Senate colleagues. And above all, they clashed over when life begins and how that definition holds up to technologies once unforeseen.

At issue is whether to ban research involving somatic cell nuclear transfer, often referred to as therapeutic cloning. The procedure is used to harvest stem cells, offering hope of one day curing diseases.

Senate Republican leaders have been hesitant to cast votes on an issue that pits Republican Gov. Matt Blunt against some of his anti-abortion supporters while splitting two of the party's key constituencies. <b>On one end are abortion opponents who oppose the procedure on moral grounds</b>; on the other are business leaders and Blunt, who see the research as an engine of economic development.

Bartle agreed to shelve his bill after several lawmakers threatened to filibuster it. In doing so, he worked out a deal with Senate Majority Leader Charlie Shields, R-St. Joseph, to seek a compromise bill to bring back to the floor later this session.

Shields said he'd like to see an alternative bill that would ban cloning that results in a human child, but allow research involving cloned cells.

But Bartle said he would not concede to such a bill. Instead, he said he would seek support for a three-year ban on the cloning research to give lawmakers a chance to study the issue.

<h3>Bartle opened debate on the bill with 40 minutes of remarks that sought to equate the human cells produced through somatic cell nuclear transfer as human life worthy of legal protection.</h3>

Under somatic cell nuclear transfer, the nucleus of an unfertilized human egg is removed and replaced with the nucleus of an ordinary human cell. The cell is then stimulated to divide into a group of cells from which stem cells are harvested. Many hope those cells could be used in the future to form into a variety of human cells, potentially repairing human hearts, lungs and spinal cords.

Bartle argued that the cells produced through the process are human life that if implanted in a womb could result in a human child.

Bartle said that if senators doubt whether the process does, in fact, result in life, they should "err on the side of protecting human life."

But most of the Senate debate was dominated by opponents of Bartle's bill. Leading the charge was Sen. Chris Koster, who had for weeks been viewed as undecided on the stem cell issue.

Koster, R-Harrisonville, argued that the cells produced through somatic cell nuclear transfer would only take on human characteristics if they were implanted in a womb.

"What makes us human occurs in the womb, not the petri dish," Koster said.

Koster borrowed Bartle's own rhetoric, arguing that if senators lack the science to declare the cells human life, they should err on the side of protecting the lives of those who await cures for disease.

Koster alluded to Sen. Chuck Graham, D-Columbia, who lost the ability to walk after an auto accident as a teenager. Without mentioning Graham by name, Koster spoke in intimate detail of the nature of Graham's disability.

Graham joined Koster in arguing against the bill. He recounted how he has waited as the promises for breakthrough in spinal cord injuries have not been realized. He said supporters of the research ban have focused on the "margins of life," while ignoring the hope such research offers to thousands.

Prior to Wednesday's debate, some had questioned whether Bartle's bill would even reach the Senate floor, given the opposition of many Republicans.

Blunt has said he would likely veto the bill. The governor said he does not believe the process produces human life, since no egg and sperm are involved in producing the cells.

An earlier version of Bartle's bill would have spelled out felony criminal penalties for those who engage in the research. A substitute version presented Wednesday instead spells out up to a $50,000 civil fine.

During debate, some anti-abortion senators expressed frustration over Bartle's unwillingness to compromise by offering a bill that would ban reproductive cloning but allow cloning research.

Sen. John Griesheimer, R-Washington, who had been a co-sponsor of Bartle's bill, blamed Bartle's inflexibility for creating a rift between Republicans.

"It's sad that we're fighting against ourselves," he said. "And it's sad that it's come to this."

Bartle's bill is SB160.
<b>Two pieces follow that helped me to understand the science better, and potential treatment of disease:</b>
Quote:

http://bluegalinaredstate.blogspot.c...endment-2.html
Thursday, October 26, 2006
The Missouri Vote: Amendment 2

Here in Missouri, we are going to the polls on November 7, just like everyone else. However, here in Missouri, we have a constitutional amendment to consider and the emotions are running high on both sides.

Amendment 2, The Missouri Stem Cell Research and Cures Initiative, is the hot-button issue this year. On one side you find the Catholic Church and Missouri Right to Life. On the other side you have a whole host of medical research foundations and Jack Danforth.

In the breach, you have me. I will say up front that I am in the "Pro" camp. I will, however, attempt to explain why I take the stand I do. In plain English. And without going on for pages.

First lets clear up a huge misconception. Somatic Cell Nuclear Transfer (SCNT) is technically "cloning" - up to a point. In the sense that cloning means replication. But it stops there.

The amendment specifically outlaws human cloning. When the opposition says it legitimizes cloning, they are disingenuous at best, and more likely they are flat-out, intentionally, being dishonest.

In SCNT, eggs are extracted and the nucleus is removed from the egg with a very tiny glass pipette. The same procedure is used to remove the nucleus of a source cell, and the nucleus is injected into the vacated (enucleated) egg cell. If we say just the right magic words in the perfect pitch and cadence, this cell will begin to replicate. At five days, we have a blastocyst of stem cells, and we can harvest those undiferentiated cells. Remember that word. It is going to be revisited a bit down the page.

Passage of Amendment 2 will assure that Missourians have access to any and all stem cell therapies that might be developed in the future (embryonic stem-cell research is only about five years old) that would be available to other patients from other states. Passage of Amendment 2 will ensure that medical institutions in Missouri would be able to conduct research to help develop new cures to horrific diseases so long as those treatments are not prohibited by federal law. Many scientists, myself included, feel these cells provide the most promising treatments for traumatic brain and spinal cord injuries, organ failure, neuro-muscular diseases, Alzheimers, organic brain disorders, and a whole host of others...including, yes, Parkinsons.

If Amendment 2 is not passed, members of the Missouri legislature would be able to outlaw therapies that are developed that use embryonic stem cells. Those with private insurance or resources could gain treatment out of state, such as in Massachusettes or California. Those who are reliant on Missouri Medicaid (a high percentage of disabled and diabetic patients) will be out of luck. The state would not pay for the treatment. So the bottom line is the state legislature could pass laws that prohibited low income people from accessing cures available to those who are better off.

I don't believe that the opponents are intentionally discriminating against these future patients. I don’t think they have even thought about them, but they should. Especially since they are not only picking up the tab for long-term treatment, they are consciously denying them any hope for a cure, possibly without even realizing it. I have heard people say they don't oppose it across the board, they just don't want it here. I have changed a few minds when this has come up in conversation. I see what I have come to refer to as "the look" cross their faces, and they often say "Wow. I never thought of that." or "Why isn't that part of the debate?"

I don't know why it isn't part of the debate. I don't fancy myself the smartest person in Kansas City, let alone the entire state, but nobody else seems to be considering this facet of the argument.

The research is going forward, in this country, and cures will be found. Failure to pass this amendment will impact the economy of our state because research will move away under threat that the work could be criminalized. This will hurt the economy of Missouri while helping the economies of states on both coasts. If the amendment fails, and the legislature bans all embryonic stem cell research, this state will deny Missouri residents therapies that will be readily available to patients in other states.

Those who oppose the Amendment say something along the lines of "Embryonic stem-cell research hasn't produced a single cure, and besides we already have adult stem cell therapies available, and adult stem cells are readily available."

This is true - but we are also exploring a totally new science in embryonic stem cell research. (Edison's lightbulbs didn't work at first, you know.) Embryonic stem cell research is so promising precisely because we have had success with adult stem cells. Bone marrow transplantation is a form of adult stem cell therapy. Success with them is how we even got to where we are. Currently, adult stem cells are most often used in cancer treatment, and indeed many lives have been saved because of these therapies.

Embryonic stem cells are undifferentiated. In other words, they can become anything. Let's say that you or someone you love has diabetes and is facing a future of insulin dependence that will lose effectiveness and it will lead to amputation, organ failure and death. Embryonic stem cells can, in theory, be used to grow healthy cells for implantation into your pancreas. The idea is that healthy cells can be introduced and will replicate to replace the unhealthy ones. This is the only hope that currently exists for a cure for diabetes and many other diseases, as well as spinal cord injuries.

Or perhaps you will be in an auto accident and your spinal cord is severed. Or your child falls while roller skating and lands just right and is paralyzed. Embryonic stem cells are the only cells that have been coaxed into replicating as nerve cells. Animal studies have successfully restored movement after spinal cords were surgically severed. This is something we never thought possible even ten years ago. The factsheet from Missouri Coalition for Lifesaving Cures is here.

This is an area where I have a little more than an opinion. I am a working scientist, a science educator and a grad studednt in science. I am also a member in good standing of the <a href="http://www.ascp.org/">American Society of Clinical Pathologists</a>. I have been an associate researcher (read uncredited student lackey) on papers published in respected journals by my professors.

Yeah. I got some game here. Any questions you might have about this issue, pose them in comments and I will attempt to give an unbiased answer that provides information to allow you to make an informed and well-though-out decision as to where you stand on the issue.
Quote:

http://www.newscientist.com/channel/...n-disease.html
<b>Stem cell trial to combat childhood brain disease</b>

* 12:13 25 September 2006
* NewScientist.com news service
* Helen Phillips

The first clinical safety trial of a purified human fetal stem cell product is about to begin in the US for a rare and fatal childhood brain disease. The trial could pave the way for neural stem cell transplants to treat a range of brain and spinal cord disorders.

A team from the Oregon Health and Science University Doernbecher Children’s Hospital plan to treat six children suffering from the inherited neurodegenerative condition, Batten’s disease – also known as neuronal ceroid lipofuscinosis (NCL). There is currently no alternative treatment for the disease.

The team expect to treat the first child before the end of 2006. The children will receive injections of neural stem cells that have been purified – isolated from other cell types – and grown from donated human fetal tissue. The stem cell product and isolation technique was developed by StemCells Inc, of Palo Alto, California, which is sponsoring the trial.

Children with Batten’s disease suffer seizures, motor control disturbances, blindness and communication problems. As many as 600 children in the US are currently diagnosed with the condition – death can occur in children as young as 8 years old.

The children lack an enzyme for breaking down complex fat and protein compounds in the brain, explains Robert Steiner, vice chair of paediatric research at the hospital. The material accumulates and interferes with tissue function, ultimately causing brain cells to die.
Neuron support

Previous tests on animals demonstrated that stem cells injected into the brain secreted the missing enzyme. And the stem cells were found to survive well in the rodent brain.

Once injected, the purified neural cells may develop into neurons or other nervous system tissue, including oligodendrocytes, or glial cells, which support the neurons, say the researchers. Steiner is hopeful that the treatment will work for the 25 or so other hereditary brain diseases related to Batten’s disease.

In addition to secreting enzymes, Steiner says these cells can become the type of nerve cells found in spinal cord, and so they could potentially help after spinal cord injury. The stem cells can form into neural cells found in the brain or nerve cells found elsewhere in the central nervous system, he explains.

However, Stephen Minger, director of the stem cell biology laboratory at Kings’ College London, believes that despite Steiner’s claims about the versatility of the new purified cells, their use is limited to Batten’s disease. “The cells in question have little clinical relevance to other neurological disorders,” he says. ....

FoolThemAll 10-30-2006 06:22 AM

Quote:

Originally Posted by Yakk
Where, exactly, is the "collateral damage" in taking discarded human cells, and using it?

The cells are going to be killed. You may object to the process that led to cells going to be killed, but once you have some being who has no ability to think, is doomed to die, and has useful organs or cells -- where is the ethical problem with harvesting it?

You do know that what I described is the source of almost all human organ transplants.

There may be a very good point here. Two caveats:

1. The cells that "are going to be killed" - are they to be killed because they can no longer be implanted successfully, or killed by request or for storage issues? If it's one of the latter two, then I don't see the inevitability that you do. I would argue that destruction of cells with a potential future should not be allowed. And that just goes back to my problem with in vitro in general. If it's the former, though, then I'm close to agreeing with you.

2. The only remaining problem I'd have - and I'm undecided on this - is that I might still oppose the use of the embryos because it could encourage/increase the creation of nonviable embryos. Tossing that around in my head right now.

roachboy 10-30-2006 06:31 AM

Quote:

I would argue that destruction of cells with a potential future should not be allowed
what a strange statement.
do you mean this?

FoolThemAll 10-30-2006 06:34 AM

edit: Oh, I see. Context is needed.

By 'cells', I mean the cells of an embryo. I don't mean just any ordinary collection of cells - I mean a human organism.

AXP_Crow23 10-30-2006 09:44 AM

read to today in the paper (Metro) Fox admits that he doesnt even know what the stem cell legislation will do. Always nice to support something when you know nothing about it. Gives you lots of credibility.

host 10-30-2006 10:32 AM

Quote:

Originally Posted by AXP_Crow23
read to today in the paper (Metro) Fox admits that he doesnt even know what the stem cell legislation will do. Always nice to support something when you know nothing about it. Gives you lots of credibility.

Read my posts.....you aren't adding anything to the discussion, IMO. Why not go the rest of the way.... and comment on the other "content" on the linked page that xxSquirtxx posted earlier:
http://www.floppingaces.net/2006/10/...ng-initiative/
Quote:

So basically Michael made an ad, in which he was purposely overmedicated, to support McCaskill because of her stand on this initiative. An initiative he never read nor understood.
This campaign issue is not a partisan issue....it is fueled by religion influenced ignorance.... The partisan dimension is that one party panders to the issues of religious zealots in order to attract their political support.

In Missouri, there is a running political battle between religious zealots who are trying to transform that state into a "Jesus Land". Michael J. Fox is interested in all Americans enjoying the same potential for medical research breakthroughs to bring relief from symptoms of illness, and to reverse deterioration and death that too often is the result of disease that medicine has inadequate or no treatment for.

<h3>That is his "agenda"....what is yours? Why are you posting a repetition of earlier attacks on Michael J. Fox, here, and by Rush Limbaugh?</h3>
Quote:

http://www.cbsnews.com/stories/2006/...n2128188.shtml
Oct. 26, 2006

........."The irony is that I was too medicated. I was dyskinesic," Fox told Couric. "Because the thing about … being symptomatic is that it's not comfortable. No one wants to be symptomatic; it's like being hit with a hammer."

His body visibly wracked by tremors, Fox appears in a political ad touting Missouri Democratic Senate candidate Claire McCaskill's stance in favor of embryonic stem cell research. That prompted Limbaugh to speculate that Fox was "either off his medication or acting."

Fox told Couric, "At this point now, if I didn't take medication I wouldn't be able to speak."

He said he appeared in the ad only to advance his cause, and that "disease is a non-partisan problem that requires a bipartisan solution."

"I don't really care about politics," Fox added. "We want to appeal to voters to elect the people that are going to give us a margin, so we can't be vetoed again.

Though Fox, a native of Canada who became an American citizen in 2000, has been politically active for Democratic causes, <b>he said he has voted for and would vote for a Republican. "Arlen Specter is my guy," he said of the Republican senator from Pennsylvania. "I've campaigned for Arlen Specter. He's been a fantastic champion of stem cell research. I've spoken alongside Mike Castle, who's a Republican congressman. Absolutely."</b>

"This is not about red states and blue states," added Fox, who has also lobbied Congress to lift President Bush's restrictions on funding for stem cell research. "This is not about Democrats and Republicans. This is about claiming our place as the scientific leader in scientific research and moving forward and helping our citizens. That’s all it is. It’s that simple." .....
<b>Why not add to this discussion, instead of attacking Michael J. Fox? Your post and others of similar vein are unseemly. You're attacking a very ill man with an incurable disease who is using his celebrity to attempt to counter the political influence and activities of religious zealots who have abridged the access to medical research, medical appliances, medicine, hygenic education, and to safe, approved, medical procedures that their relgious beliefs influence them to object to and motivate them to attempt other people from receiving.....IMO, Michael J. Fox is being much too polite in his response to the efforts and the propagandizing of these misguided, ignorant, selfish, and religiously intolerant people. In Missouri, they've already succeeded in keeping birth control options from the working poor.....options routinely offered in many other states to low income workers who are poor, but do not qualify for medicaid..... aid that was offered in Missouri clinics before these religiously energized folks were elected to the state legislature....</b>

xxSquirtxx 10-30-2006 11:20 AM

Quote:

Originally Posted by host
In Missouri, there is a running political battle between religious zealots who are trying to transform that state into a "Jesus Land". Michael J. Fox is interested in all Americans enjoying the same potential for medical research breakthroughs to bring relief from symptoms of illness, and to reverse deterioration and death that too often is the result of disease that medicine has inadequate or no treatment for.

<h3>That is his "agenda"....what is yours? Why are you posting a repetition of earlier attacks on Michael J. Fox, here, and by Rush Limbaugh?</h3>

<b>Why not add to this discussion, instead of attacking Michael J. Fox? Your post and others of similar vein are unseemly. You're attacking a very ill man with an incurable disease who is using his celebrity to attempt to counter the political influence and activities of religious zealots who have abridged the access to medical research, medical appliances, medicine, hygenic education, and to safe, approved, medical procedures that their relgious beliefs influence them to object to and motivate them to attempt other people from receiving.....IMO, Michael J. Fox is being much too polite in his response to the efforts and the propagandizing of these misguided, ignorant, selfish, and religiously intolerant people. In Missouri, they've already succeeded in keeping birth control options from the working poor.....options routinely offered in many other states to low income workers who are poor, but do not qualify for medicaid..... aid that was offered in Missouri clinics before these religiously energized folks were elected to the state legislature....</b>

Holy shit. Enough hate in this post or what?

How dare you sit there and accuse me and others of "attacking" MJF when all we are doing is pointing out his inconsistency AND the inconsistency of Amendment 2, which is about human cloning.

Sick though he may be, he entered the political arena uninformed about the candidates' positions. Pointing that out is not attacking him. Somehow I doubt you would use kid gloves with Limbaugh if the situation were reversed and he was doing a commercial about prescription pain meds or some such BS.

You and others are clearly the ones with an ax to grind when it comes to people who are opposed to killing babies for stem cells. Your post appears to be nice and tidy, but those issues are NOT very tidy at all. There are many facets to things like stem cell research and abortion.

You continue to berate certain people here who have beliefs different from yours. You had better expect a vigorous response when you distort the issues and spew untruths.

dc_dux 10-30-2006 11:28 AM

Quote:

...all we are doing is pointing out his inconsistency AND the inconsistency of Amendment 2, which is about human cloning.
I would only suggest that your assessment that Amendment 2 is about human cloning is just that -- AN OPINION based on your interpretation of the initiative. There are other interpretations by medical and bio-ethic experts that are equally valid.

It is also a shame the blog reference in your earlier post did not present the complete ABC interview with Michael J. Fox:

http://abcnews.go.com/ThisWeek/story?id=2613377&page=1

He demostrated alot more tolerance and understanding of those who dont share his position than I have seen demonstrated by those who characterize any embryonic stem cell research as "baby killing."

xxSquirtxx 10-30-2006 11:31 AM

Quote:

Originally Posted by dc_dux
I would only suggest that your assessment that Amendment 2 is about human cloning is just that -- AN OPINION based on your interpretation of the initiative. There are other interpretations by medical and bio-ethic experts that are equally valid.

Indeed, I did not mean to imply that it is solely about human cloning.

kutulu 10-30-2006 12:15 PM

Quote:

Originally Posted by xxSquirtxx
You and others are clearly the ones with an ax to grind when it comes to people who are opposed to killing babies for stem cells. Your post appears to be nice and tidy, but those issues are NOT very tidy at all. There are many facets to things like stem cell research and abortion.

Killing babies for stem cells? Are you kidding me? Stem cells for research are made by the same method that is used for in vitro fertilization. When someone goes to the fertility clinic, does some right-winger say that they are killing babies to make a baby?

xxSquirtxx 10-30-2006 12:16 PM

Quote:

Originally Posted by kutulu
Killing babies for stem cells? Are you kidding me? Stem cells for research are made by the same method that is used for in vitro fertilization. When someone goes to the fertility clinic, does some right-winger say that they are killing babies to make a baby?

I understand.....I was typing off my reply in quite a hurry.

Ustwo 10-30-2006 12:29 PM

The rather funny thing in all this I didn't bring up is that there may not even be a need to harvest fertlized cells as there are already stemcell lines out there. These are the pluripotent cell types.

The best cells for curing disease would come from fetuses which are further developed. We don't really understand what makes a liver become a liver, but if you had a fetus at the exact stage the liver started to form, those cells would be most valueable to study.

The pluripotent stem cell research is really just that, pure research. I'd put more money on adult stem cells for curing SOME disease, and for the fetal ones for curing many diseases.

My thoughts though is that once using the basic stem cell lines are 'accepted' the next step will be to use fetal cells. THAT is going to be a fun debate.

If of course you believe life begins at conception, then its all a moot point.

host 10-30-2006 12:39 PM

Quote:

Originally Posted by Ustwo
The rather funny thing in all this I didn't bring up is that there may not even be a need to harvest fertlized cells as there are already stemcell lines out there. These are the pluripotent cell types.....

Is your point compatible with these:

From post #75:
Quote:

http://www.newscientist.com/channel/...n-disease.html
Stem cell trial to combat childhood brain disease

* 12:13 25 September 2006
* NewScientist.com news service
* Helen Phillips

The first clinical safety trial of a purified human fetal stem cell product is about to begin in the US for a rare and fatal childhood brain disease. The trial could pave the way for neural stem cell transplants to treat a range of brain and spinal cord disorders....

....
The team expect to treat the first child before the end of 2006. The children will receive injections of neural stem cells that have been purified – isolated from other cell types – and grown from donated human fetal tissue. The stem cell product and isolation technique was developed by StemCells Inc, of Palo Alto, California, which is sponsoring the trial.

Children with Batten’s disease suffer seizures, motor control disturbances, blindness and communication problems. As many as 600 children in the US are currently diagnosed with the condition – death can occur in children as young as 8 years old.....
Quote:

http://www.ascb.org/index.cfm?navid=...887&tcode=nws3
Stem Cells & Cloning
Testimony on Stem Cell Research Before the Senate Committee on Health, Education, Labor and Pensions


Presented by Douglas Melton, Ph.D.

Thomas Dudley Cabot Professor in the Natural Sciences at Harvard University
Investigator in the Howard Hughes Medical Institute
September 5, 2001

....President Bush's plan for sixty embryonic cell lines
President Bush has made clear his commitment to support research on human embryonic stem cells, highlighting the importance of this research. The President's plan provides the opportunity to advance embryonic stem cell research in the US, at least for a few years, and as such his plan marks an important commitment. The Honorable Tommy Thompson has worked diligently for this research and his continued leadership will be critical in moving forward with the President's plan.

For this field the date of the President's speech, 9 August 2001, is important because only stem cell lines in existence at that time, estimated to be about sixty, are eligible for federal support. This date was not chosen for scientific reasons and its arbitrary selection will have an effect on the progress of research. For example, it will not be possible for federally funded researchers to explore new ways to derive human embryonic stem cells nor work with cells that have been isolated without possible contamination from mouse or other supporting cells. Nevertheless, it is now possible for the nation's researchers to initiate studies on how embryonic stem (ES) cells differentiate and we can begin to explore their therapeutic potential.

Looking ahead to how the plan will work, I turn to two issues: the quality of the sixty cell lines and their access or availability.

Quality of the human embryonic stem cell lines
Scientists are, by their nature, inquisitive and skeptical and we hold dear the practice of publishing results following an independent review by qualified experts. Moreover, by publishing results, scientists generally agree that the reagents reported, including cells, are available to be shared with the research community. In this way results can be independently verified and new directions and discoveries can be explored. In the present case, only a handful of the sixty+ embryonic cell lines have been published so it is not yet possible to evaluate or comment on the quality of cells. Nonetheless, legitimate scientific questions about the growth, differentiation potential, age, and purity of the lines must be considered. Decades of experience with mouse embryonic stem cells have shown that ES cells can lose their differentiation potential, become contaminated, accumulate mutations, and tend toward spontaneous or uncontrolled differentiation. The fact that mouse ES cells lose their full potential with increasing age or passage number is only one reason to believe that the sixty+ cell lines will not be sufficient for the years of research required to investigate therapies with these cells. Looking ahead to clinical applications, including transplantation and the problem of immunological rejection, there will certainly be a need for broader genetic diversity of cell lines. There may also be a need for cell lines that have been isolated without the use of mouse feeder layers.

I hasten to add that I am not criticizing the NIH nor the scientists who have reported the isolation of the sixty human embryonic stem cell lines. Indeed, the scientists have not published their work and they may well wish to further characterize the cells before doing so. It is therefore too early to tell how many of the sixty+ lines are truly useful embryonic stem cell lines. Preliminary indications from press reports do suggest that the final number will be significantly less than sixty. If the available lines have been grown extensively and have a high passage number that will further reduce their value.....

Ch'i 11-03-2006 05:18 PM

I remember reading an article on an experiment that may have sucessfully turned human skin cells into stem cells (I'll keep searching for the article).

Edit:
Quote:

National Geographic News
Scientists have turned an ordinary skin cell into what appears to be an embryonic stem cell. The process may eventually eliminate the controversial step of destroying human embryos for stem cell research.

The new technique involves fusing a skin cell with an existing, laboratory-grown embryonic stem cell. The fused, or hybrid, cell is "reprogrammed" to its embryonic state, Harvard University scientists report in the journal Science.

Their paper was published Sunday on the journal's Web site.

The breakthrough may one day quell the debate over stem cell research. But team member Kevin Eggan said the technology is still in early stages and is not a replacement for methods currently used to derive embryonic stem cells.

"This is just beginning of this system," he told reporters in a conference call.

Embryonic stem cells are unspecialized cells. They can grow into any type of cell found in our body.

Scientists hope embryonic stem cells can eventually be used to grow new tissue and replacement organs and to cure a range of ailments, from spinal cord injuries to Alzheimer's disease.

To study embryonic stem cells, researchers developed cell lines from stem cells, which were initially harvested from fertilized human eggs, such as those leftover from in vitro fertilization.

Because harvesting destroys the embryo, in the United States the practice has drawn the ire of many religious conservatives who regard destroying embryos as a form of murder.

New Way

The Harvard research suggests a new way to create embryonic stem cells that may one day eliminate the need to destroy fertilized human eggs.

The new type of stem cells is essentially a rejuvenated version of a person's own skin cells. A stem cell created by the new method would have DNA identical to that of the skin cell donor.
Here are some recent breakthroughs for your pleasure.
Quote:

Scientists Discover Key to Growing New Stem Cells

Scientists at Duke University Medical Center have demonstrated they can grow human stem cells in the laboratory by blocking an enzyme that naturally triggers stem cells to mature and differentiate into specialized cells.

The discovery may enable scientists to rapidly grow stem cells and transplant them into patients with blood disorders, immune defects and select genetic diseases, said the Duke researchers.

Stem cells are the most flexible cells in the body, continually dividing into new stem cells or into specialized cells that carry out specific roles in the body. But little is known about how stem cells choose their fate. The Duke team focused on "hematopoietic" or blood stem cells.

In their study, the investigators discovered that an enzyme, aldehyde dehydrogenase (ALDH), stimulates hematopoietic stem cells to mature and transform into blood or immune cells, a process called differentiation. They inhibited this enzyme in stem cell cultures and successfully increased the number of stem cells by 3.4 fold. Moreover, they demonstrated the new stem cells were capable of fully rebuilding the blood-forming and immune systems of immune-deficient mice.

Results of the study are published on line and will be published in the August 10, 2006, issue of the Proceedings of the National Academy of Sciences.

"Our ability to treat human diseases is limited by our knowledge of how human stem cells determine their fate -- that is, whether they maintain their ability to self-renew or whether they go on to become specialized cells," said John Chute, M.D., associate professor of medicine in the Duke Adult Bone Marrow and Stem Cell Transplant Program. "Unraveling the pathways that regulate self-renewal or differentiation in human stem cells can facilitate our ability to expand the growth of human stem cells for therapeutic uses."

Currently, patients who require stem cell transplants are given either bone marrow from adult donors, umbilical cord blood derived from newborn babies, or stem cells from blood. But stem cells are scarce, representing less than 0.01 percent of the bone marrow cell population. Likewise, cord blood units frequently lack sufficient numbers of stem cells to rebuild a patient's decimated immune system.

Efforts to grow human hematopoietic stem cells in the laboratory have proven extraordinarily difficult, Chute said, because growth factors in culture make stem cells rapidly differentiate. The scientists searched for ways to block a stem cell's natural propensity to differentiate without promoting uncontrolled growth.

The researchers focused on the ALDH enzyme because it is a telltale "marker" that distinguishes stem cells from other blood and immune cells. Moreover, it is known to play an essential role in the body's production of retinoic acids, which regulate cell differentiation in a variety of tissues. Yet how ALDH functions in stem cells remained unknown, Chute said.

The scientists began by analyzing how stem cells behave under normal circumstances when grown in culture. They mixed together purified human stem cells with growth factors that induce stem cells to mature and differentiate. As expected, the stem cells showed a marked decline in number as they differentiated into other types of specialized cells. By day seven, all stem cells had disappeared from culture.

The scientists then added an inhibitor of ALDH to the stem cell cultures, and they found that half of the stem cells maintained their immature and undifferentiated status. Moreover, adding the inhibitor caused a 3.4-fold increase in stem cell numbers within seven days.

Next, the scientists transplanted the cultured stem cells into immune-deficient mice to determine how the stem cells would behave. The new population of stem cells migrated to the bone marrow as expected and successfully "engrafted," or took hold in the bone marrow, where they began to produce new blood and immune cells.

"ALDH appears to play a fundamental role in the differentiation program of human hematopoietic stem cells," Chute said. "Inhibition of this enzyme facilitates the expansion of human hematopoietic stem cells in culture."

Chute said their results reveal a unique role for both ALDH and the process of retinoic acid signaling in human stem cells. Chute and colleague Donald McDonnell, Ph.D., professor of pharmacology and cancer biology, are currently testing whether they can directly block the retinoic acid receptors in stem cells and produce a comparable expansion of human stem cells.

The investigators plan to develop a clinical trial to test their approach to expand human stem cells for therapeutic purposes.

Source: Duke University Medical Center
Quote:

Stem cells engage in dialogue with cells that regulate their future

http://www.physorg.com/newman/gfx/ne...cell1_w250.jpg

These two images show fruit fly stem cells (orange/pink stained cells) in their niche (first image) and leaving their niche (second image). Note the orderly manner in which the stem cells line up and then leave the niche.
Dialogue, not a monologue, is the basis of all good communication. Stem cells are no exception. Recent University of Washington (UW) research has found an early indication of two-way cellular communication. This two-way cell-to-cell signaling occurs in the miniscule niches of the body where the futures of stem cells are determined.

Stem cells require these niches - nest-like microenvironments made up of regulatory cells -- in order to self-renew. Stem cells can divide and turn into many types of new cells. The niches help regulate the amount and kinds of new cells produced to meet current demands.

The niches also help maintain a supply of stem cells for later use. Inside your body, for example, there are separate niches for stem cells that will become blood, for cells that will become skin, and so on. Niches are places where your stem cells can replenish themselves and your tissue cells throughout your lifetime.

Problems in the niches can lead to diseases in the body. For example, if cell multiplication in a niche gets out of hand, cancer might form. A decline in cell production might contribute to the frailty of old age.

While a few stem-cell niches have been known for a long time, what's been harder to discover are the characteristics of the cells making up these niches and how they make it possible for stem cells to do their job. Signaling between cells in the niche plays a role in stem-cell upkeep and development. Most research has focused on the signaling of niche cells to stem cells.

"We looked at the possibility that two-way communication exists between stem cells and niche cells,"said UW stem-cell niche researcher Hannele Ruohola-Baker, professor of biochemistry and a member of the UW Institute for Stem Cell and Regenerative Medicine. "Demonstrating that stem cells can contribute to niche function has far-reaching consequences for stem-cell therapies and may provide insight on how cancer might spread throughout the body via populations of cancer stem cells.”

Ruohola-Baker added that stem cells hold high hope in regenerative medicine: tapping into the ways cells repair the body to create therapies to fix or replace injured tissues. She mentioned that it is thought that most, if not all, adult tissues contain stem cells.

Through self-renewing division,"she explained, "stem cells replenish the stem cell pool. They also produce progeny that change into other, specialized cells. Importantly, stem cells have the capacity to divide throughout the life of an organism. They do so through regulated external stimuli that may initiate from stem cells. This regulation of cell division needs to be tightly controlled."Too little division results in poor maintenance of tissues, while too much can result in tumors or other malignancies.

Her lab used the germline stem cell niche, found in the ovaries of fruit flies, as a model system. The production of fruit fly eggs depends on the presence of a renewable source of stem cells in the ovary of the adult fruit fly.

Inside the fruit fly ovary are structures called germarium which contain tiny cradles made of cap cells that nurture stem cells. Each such cradle contains two to three stem cells preparing to become fly eggs that are cuddled in a niche composed of three to six cap cells. Cap cells adhere to stem cells and this close contact may allow cap cells to play critical roles in communicating with stem cells.

The research team looked at a kind of signaling that usually depends on direct contact between cells, called the Notch pathway. The Notch protein is like a trigger poking out of a cell that can activate a mechanism inside the cell. When this trigger is pulled by proteins, called Delta and Serrate, from another cell, proteins are freed inside the cell to travel to the cell nucleus and turn on various genes.

According to Ruohula-Baker, the Notch pathway plays an important role in many stem-cell niches, including those in the blood system, gut, breasts, and muscles. However, in many cases it hasn't been clear which cells send and which ones receive the signaling protein.

The UW researchers analyzed the role of the Notch signaling pathway in both the stem cells and the cap cells. They found that either an increased production of Delta protein in the stem cells, or the presence of activated Notch protein in niche cells, resulted in up to 10 times the normal number of niche cells. These extra niche cells in turn resulted in a larger population of stem cells.

On the other hand, when stem cells don't produce functional Delta protein, they cease to be stem cells and soon leave the niche. The researchers also found that the receiving end for the Notch pathway, the trigger, is required in the niche cells, making them receivers of signals, not just senders. Work by other scientists had shown that TCF-beta signaling from niche cells is required to maintain active stem cells.

"Our study now shows that stem cells use the Notch pathway to signal to neighboring cells to maintain an active niche, and in turn, the niche induces and maintains the fate of the stem cells,"Ruohola-Baker noted. "This is a first indication of a dialogue taking place between the stem cells and the niche that supports them. It is tempting to speculate that maybe multiple potential niches exist for stem cells in our bodies that can be turned on to action when signaling stem cells are in the neighborhood. It may very well be that the power of cancer cells to spread comes from this natural ability of stem cells to make a home when in a hospitable environment. We all need a home, and stem cells with their strong survival instinct are active homebuilders.”

The study will appear in the Dec. 5 issue of Current Biology, but is already online at the journal Web site. The research was supported by grants from the American Heart Association, the National Institutes of Health, and the American Cancer Society.

Source: University of Washington
Quote:

Scientists at an English university have grown a miniature artificial human liver in a major medical breakthrough, British media reported Tuesday.

It is hoped mini-livers could be used to test drugs, reducing the need for animal experiments, help repair damaged livers and eventually produce entire organs for lifesaving transplants, the Daily Mail newspaper reported.

The organ, which is about the size of a thumbnail, was grown using stemcells in blood taken from umbilical cords.

Professor Colin McGuckin, who specializes in regenerative medicine, made the breakthrough with Doctor Nico Forraz at Newcastle University in northeast England.

While other scientists have created liver cells, the Newcastle team are the first to create sizeable sections of tissue from stem cells from the umbilical cord, the Daily Mail said.

The pair extracted blood from the umbilical cords of newborn babies. They were then placed in a "bioreactor" developed by NASA, which mimics the effects of weightlessness. This allows the cells to multiply more quickly.

Chemicals and hormones are then added to encourage the stem cells to turn into liver tissue.

"We take the stem cells from the umbilical cord blood and make small mini-livers," said McGuckin. "We then give them to pharmaceutical companies and they can use them to test new drugs on.

"When a drug company is developing a new drug it first tests it on human cells and then tests it on animals before beginning trials on humans," he said.

And he added: "Moving from testing on animals to humans is a massive leap and there is still a risk. But by using the mini-livers we have developed there is no need to test on animals or humans."

They could potentially be used like dialysis machines, buying time for a patient's liver to repair itself or for doctors to find a replacement liver.

Professor Ian Gilmore, a liver specialist at the Royal Liverpool Hospital in northwest England, told the BBC that the Newcastle team had made a "big ethical leap forward" in not requiring embryos to produce tissue.

"It is exciting because there is a real dearth of treatments available for people with liver disease," he said.

It is estimated that up to 10 percent of the British population have liver problems, mostly linked to lifestyle factors such as obesity and alcoholism, the BBC said.

© 2006 AFP


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